PMID: 8952027Nov 1, 1996Paper

Experimental infection of pregnant cattle with the vaccine candidate Brucella abortus strain RB51: pathologic, bacteriologic, and serologic findings

Veterinary Pathology
M V PalmerA E Jensen

Abstract

To determine the placental tropism and abortigenicity of the vaccine candidate Brucella abortus strain RB51 (SRB51), a rough mutant of the virulent strain 2308, ten Polled Hereford heifers were inoculated intravenously in the 6th month of gestation. Heifers were euthanatized and examined at postinoculation week (PIW) 8 (n = 5) or at full term (n = 5). Four of five infected heifers sampled at PIW 8 and three of four infected heifers at term had placentitis, whereas reproductive tissues of three normal cows used for comparison had no placentitis. Numerous macrophages, immunoreactive for SRB51 antigen, as well as neutrophils, fibrin, and cell debris filled the arcade zone between chorion and maternal septae. Trophoblastic epithelium of the placentomal arcade zone had intracellular bacteria that were immunoreactive for SRB51 antigen. The tips of maternal septa had a lymphoplasmacytic infiltrate with small multifocal erosions and ulcerations of maternal epithelium. SRB51 was cultured from all tissues in which lesions were seen. Placentae of one cow from each group had no placentitis and contained no SRB51. In mammae, interstitial lymphoplasmacytic infiltrates and suppurative infiltrates within alveoli and intralobular ductules were ...Continue Reading

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Citations

Apr 23, 2003·Preventive Veterinary Medicine·G T FosgateM D Diptee
Nov 5, 2002·Veterinary Microbiology·Gerhardt G SchurigMichael J Corbel
Apr 20, 1999·Research in Veterinary Science·S C OlsenN F Cheville
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Aug 16, 2017·Tropical Animal Health and Production·Adriana Agostini BarbosaCarlos Antonio Carvalho Fernandes
Nov 7, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Fatma Ilhan, Zabit Yener
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Oct 23, 2020·Veterinary Medicine and Science·Francis B KoloHenriette Van Heerden

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