Experimental Infection of White-Tailed Deer (Odocoileus virginanus ) with Heartland Virus

The American Journal of Tropical Medicine and Hygiene
Lorelei L ClarkeElizabeth W Howerth

Abstract

Heartland virus (HRTV) is a phlebovirus suspected to be transmitted by Amblyomma americanum, commonly known as the lone star tick, and reported to cause illness in humans, which is characterized by thrombocytopenia and leukopenia. Heartland virus-reactive antibodies have been detected in a variety of wildlife species including white-tailed deer (WTD). To better understand the potential role of deer in the epidemiology of HRTV, we experimentally inoculated five WTD fawns with HRTV and monitored for clinical disease, viremia, virus shedding, and seroconversion. None of the animals showed signs of clinical disease, and there was no detectable viremia or virus shedding postinoculation. Two wild-caught fawns entered the study with preexisting antibody titers against HRTV. All animals showed minimal immune responses against HRTV after needle inoculation. In conclusion, this study does not indicate that WTD are a likely reservoir for HRTV in natural settings.

References

Apr 1, 1996·The American Journal of Tropical Medicine and Hygiene·J E OsorioT M Yuill
Apr 8, 2003·Vector Borne and Zoonotic Diseases·J N NagayamaC S Apperson
Aug 31, 2012·The New England Journal of Medicine·Laura K McMullanStuart T Nichol
Jul 24, 2013·The American Journal of Tropical Medicine and Hygiene·Harry M SavageWilliam L Nicholson
Jun 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Atis MuehlenbachsSherif R Zaki
Sep 25, 2015·Emerging Infectious Diseases·Kasen K Riemersma, Nicholas Komar
Nov 22, 2016·Emerging Infectious Diseases·Angela M Bosco-LauthAaron C Brault

❮ Previous
Next ❯

Citations

Sep 27, 2018·The American Journal of Tropical Medicine and Hygiene·Lorelei L ClarkeElizabeth W Howerth
Sep 19, 2018·Viruses·Aaron C BraultJ Erin Staples
Aug 21, 2020·The American Journal of Tropical Medicine and Hygiene·Samantha E AllenNicole M Nemeth
Oct 15, 2021·Emerging Infectious Diseases·Alan P DupuisAlexander T Ciota

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.