Experimental infection with Ehrlichia phagocytophila in cattle

Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B
H Brun-HansenF Hardeng

Abstract

Twenty Norwegian Red cattle, aged 8-10 months were used. Ten animals were inoculated intravenously with 3 ml of a whole blood dimethyl sulphoxide stabilate of a bovine strain of Ehrlichia (Cytoecetes) phagocytophila. The animals were observed on a daily basis for clinical symptoms and rectal temperatures were recorded daily for 36 days post inoculation. Blood and serum samples were collected regularly during the observation period. All infected animals developed fever of 2-4 days duration within a week. Six out of 10 animals had secondary temperature rises of 1-2 days duration. Three animals showed swellings in the hind limbs and a stiff gait. Compared with the control group, there was a 10% decrease in the mean haematocrit and a leukopenia that initially was due to a lymphopenia and later to a neutropenia. A monocytosis occurred after the subsidence of the primary fever period. A thrombocytopenia occurred during the early phase of infection. Granulocytic inclusions were detected for 18-32 days. All infected animals developed antibodies > or = 1:4096 to E. phagocytophila within 14 days post infection.

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Citations

Jun 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H Brun-HansenH Grønstøl
Jul 1, 1997·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H Brun-HansenB Hoff
Nov 23, 2006·Annals of the New York Academy of Sciences·Zerai Woldehiwet
Oct 9, 2009·Veterinary Parasitology·Zerai Woldehiwet

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