PMID: 3747863Jan 1, 1986Paper

Experimental infections of dogs with type C influenza virus

Microbiology and Immunology
K OhwadaM Homma

Abstract

A study was performed to determine if type C influenza infection could be established in dogs as a model for human cases. Mongrel dogs were infected with the Ann Arbor/1/50 strain of type C influenza virus and were examined for clinical symptoms, virus isolation and antibody response. After the first exposure to the virus, all infected animals developed nasal discharge and some of them also showed swelling of the eyelids, and suffusion of the eyes with tears and eye mucus, within 1 to 4 days. The animals showed an increase in hemagglutination-inhibiting (HI) serum antibody, and recovery of the agent from the nasal swabs was successful. The symptoms lasted for as long as 10 days in most infected dogs, which was comparable to our human cases reported previously (Katagiri, S., Ohizumi, A., and Homma, M. 1983. J. Infect. Dis. 48: 51-56). After the second and third virus exposures at intervals of 50 days, all animals developed the same symptoms as those described above and the rise in antibody titer was evident. The virus could be recovered from four of the six dogs 2 to 5 days after the second exposure and from one dog as late as 10 days after the third exposure. Increases in antibody titer in the IgM fraction were observed after e...Continue Reading

References

Apr 1, 1979·The Journal of General Virology·K NeromeM Ishida
Aug 1, 1976·Virology·W H Wunner, C R Pringle
Jul 1, 1983·The Journal of Infectious Diseases·S KatagiriM Homma
Nov 1, 1984·The Journal of General Virology·G Yuanji, U Desselberger
Jan 1, 1982·Microbiology and Immunology·M HommaS Katagiri
Oct 1, 1980·Archives of Internal Medicine·A C DykesC E Nolan
Dec 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·P GERBERS R ZIEGRA
Oct 22, 1955·British Medical Journal·B E ANDREWS, J C MCDONALD
Feb 1, 1949·American Journal of Public Health and the Nation's Health·R M TAYLOR

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Citations

Jan 1, 1990·Microbiology and Immunology·K TakiguchiK Nakamura
Aug 10, 2007·Journal of Virology·Bernadette Crescenzo-Chaigne, Sylvie van der Werf
Dec 4, 2010·PLoS Currents·Derek Gatherer
Jan 1, 1987·Microbiology and Immunology·S KatagiriM Homma
Nov 26, 2014·Annual Review of Animal Biosciences·Harini Sooryanarain, Subbiah Elankumaran
Sep 20, 2012·Genetika·A S SperanskaiaA V Kudriavtseva
Dec 16, 2018·Bioscience Reports·Ian A YorkIrina V Alymova

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