Experimental infusion phlebitis: tolerance osmolality of peripheral venous endothelial cells

Nutrition
Takashi KuwaharaS Kubo

Abstract

This study aimed to determine the osmolality that peripheral venous endothelial cells can tolerate and to clarify the relationship between tolerance osmolality and duration of infusion. Nutrient solutions of 539-917 mOsm/kg, prepared to have no acidic effect, were infused into rabbit ear veins, and the veins were examined histopathologically. In each experiment of 8-, 12-, or 24-h infusion, the higher osmolality solutions caused some phlebitic changes, such as loss of venous endothelial cells, inflammatory cell infiltration, and edema; however, the lowest osmolality solution caused few changes. Infusion of 120 mL/kg of 814 mOsm/kg solution caused phlebitis at 5 or 10 mL.kg-1.h-1, however, the same volume of the same solution scarcely caused phlebitis at 15 mL.kg-1.h-1 because of the shortened infusion duration. These results suggest that the tolerance osmolality of peripheral venous endothelial cells with poor blood flow is about 820 mOsm/kg for 8 h, 690 mOsm/kg for 12 h, and 550 mOsm/kg for 24 h, and that the tolerance osmolality falls as the duration of infusion increases. In conclusion, hypertonic solutions should be infused at as high a rate as is clinically acceptable and compatible with nutrient bioavailability because in...Continue Reading

References

Sep 1, 1976·European Journal of Intensive Care Medicine·I Hessov, M Bojsen-Møller
May 1, 1977·Anesthesia and Analgesia·G G DorrisM B Ravin
Nov 1, 1991·The British Journal of Surgery·J NordenströmJ Larsson
Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·A C Möller-LoswickK Lundholm
Jan 1, 1985·Acta Anaesthesiologica Scandinavica. Supplementum·I Hessov
May 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·J M DalyJ E Canham
Mar 1, 1973·The Journal of Surgical Research·J H LittleE W Fonkalsrud
Nov 1, 1968·The Journal of Surgical Research·E W FonkalsrudF G Smith
Sep 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·J J Payne-James, H T Khawaja
Sep 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·G C CarlsonN Williams
Feb 1, 1986·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B MessingM Guignier
Apr 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J G Timmer, H G Schipper
Dec 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M J KerinJ Macfie
Apr 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·N J EverittM J McMahon
Jun 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T KuwaharaS Kubo
Dec 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D PalmerC J Mitchell

❮ Previous
Next ❯

Citations

Dec 5, 2008·Archives of Toxicology·Michael MillroseRalf Stahlmann
Jan 18, 2007·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Michelle L Hawes
Apr 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Alastair Forbes
Aug 2, 2007·The American Journal of Nursing·Lynn Hadaway
Jan 30, 2004·The Journal of Trauma·Eric M Kagel, Ghazi M Rayan
Jul 17, 2009·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Darcy DoellmanMarc Stranz
Aug 13, 2008·International Journal of Medical Sciences·Emiko KohnoKenji Matsuyama
Aug 15, 2009·International Journal of Medical Sciences·Emiko KohnoNoboru Okamura
Aug 13, 2013·Journal of Pharmacological and Toxicological Methods·G EichenbaumL Lammens
Jun 1, 2014·Cancer Chemotherapy and Pharmacology·Zhuo WangDingfeng Su
Dec 3, 2014·International Journal of Pharmaceutics·John R EisenbreyMargaret A Wheatley
May 26, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mauro PittirutiUNKNOWN ESPEN
Jan 22, 2013·Alimentary Pharmacology & Therapeutics·M DibbS Lal
Apr 24, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mehmet DemircanBulent Mizrak
Aug 29, 2003·The British Journal of Surgery·A D G AndersonJ MacFie
Jun 2, 2015·International Journal of Pharmaceutics·Wei Wang
Jul 18, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kei KawadaMasanori Morimoto
Apr 10, 2014·The Annals of Pharmacotherapy·Ann Le, Samit Patel
Sep 7, 2016·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Matthew Chinn, M Riccardo Colella
Feb 11, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Antoine PetitcollinHélène Bourgoin
Dec 30, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Alexandre LapillonneUNKNOWN French neonatal departments
Dec 4, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kathleen M Gura
Dec 26, 2017·Hospital Pharmacy·Andrew M North, Justin M Yee
Jun 5, 2014·The Cochrane Database of Systematic Reviews·Guo Hua ZhengLijuan Mei
Dec 7, 2018·Journal of Thrombosis and Haemostasis : JTH·D WeissO M Rotman
Dec 1, 2012·Cellular and Molecular Bioengineering·David M FoureauGloria D Elliott
Jul 25, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Marcia RyderCharles Sylvia
Sep 24, 2004·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·N Richard Anderson
May 5, 2017·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Claudia Andira Perez, Stephen A Figueroa
Apr 20, 2021·Frontiers in Veterinary Science·Elke Rudloff, Kate Hopper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Takashi KuwaharaS Kubo
Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Mário L de Lemos
© 2022 Meta ULC. All rights reserved