Experimental inoculation of mice with trypsin-resistant and trypsin-sensitive avian reoviruses

Journal of Comparative Pathology
A Al-AfaleqR C Jones

Abstract

Groups of sucking Swiss albino mice were inoculated by the intracerebral (i.c.), intraperitoneal (i.p.) or oral route with a trypsin-sensitive avian reovirus (TR1) or a trypsin-resistant (R2) reovirus. The viruses caused a number of effects, the most severe occurring after i.c. inoculation and the least after oral inoculation. They included incoordination and tremors, oiliness of the hair, and retarded growth. Patterns of viral persistence in tissues were similar for the two viruses, with high titres in the brain on days 3 and 6 after i.c. or i.p. injection. Both viruses were still present in the brain 21 days after i.c. injection. No virus was found in any tissue when TR1 was given orally. All groups "seroconverted" except the one infected orally with TR1, but neutralization titres were low. The effects resembled those described for mammalian reoviruses in mice. The results indicate that, for short periods, wild mice may be capable of transmitting avian reoviruses between poultry flocks. Furthermore, in the production of monoclonal antibodies to avian reoviruses in mice, it is possible that pathological changes will occur.

References

May 1, 1970·The Australian Journal of Experimental Biology and Medical Science·P A PhillipsM N Walters
Jul 1, 1973·Journal of Comparative Pathology·A Mustaffa-BabjeeA R Omar
Apr 1, 1953·The Australian Journal of Experimental Biology and Medical Science·N F STANLEYJ PONSFORD
Dec 1, 1994·Avian Pathology : Journal of the W.V.P.A·R C JonesM R Islam
Mar 1, 1991·Avian Pathology : Journal of the W.V.P.A·A I Afaleq, R C Jones

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Citations

Dec 13, 2006·Veterinary Microbiology·Saskia Van de Zande, Eva-Maria Kuhn

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