PMID: 2504018Jul 1, 1989Paper

Experimental labyrinthitis in rats caused by infecting with virus causing hemorrhagic fever with renal syndrome (HFRS)

Acta Oto-laryngologica
M TamuraT Kurata

Abstract

Acute and persistent viral infection of the inner ear of rats was induced with hemorrhagic fever with renal syndrome (HFRS) virus following intraperitoneal inoculation. Newborn (within 24 h after birth) rats were inoculated intraperitoneally (i.p.) with HFRS virus (B-1 strain), and the cochlea was examined using an immunohistochemical technique for the localization of viral antigens 1 week (acute infection) and 1 year (persistent infection) after infection. Virus-specific antigens were detected in the inner ear structures of the rats suffering from both acute and persistent infection. Morphological changes in the inner ear structures of these rats were observed, with hemorrhage and infiltration of lymphocytes and macrophages. Moreover virus could be isolated from the blood of all infected rats. In the present study, we have proved that HFRS virus can infect the inner ear via the viremia.

References

May 1, 1977·Infection and Immunity·K ShimokataI Nagata
Mar 27, 1975·Nature·L E DavisR T Johnson
Mar 1, 1985·Acta Oto-laryngologica·Y NomuraK Saito
Nov 1, 1968·The Laryngoscope·E N Myers, S Stool
Oct 1, 1968·The Laryngoscope·B R Alford
Jul 1, 1983·Infection and Immunity·T KurataJ B McCormick
Jan 1, 1983·Annals of the New York Academy of Sciences·T KurataJ B McCormick
Sep 1, 1954·The Annals of Otology, Rhinology, and Laryngology·J R LINDSAY, W G HEMENWAY
Sep 1, 1960·The Annals of Otology, Rhinology, and Laryngology·J R LINDSAYP H WARD

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Citations

Feb 22, 2002·Journal of Medical Virology·A MarkotićD Dekaris
Nov 1, 1990·American Journal of Otolaryngology·L E Davis
Feb 1, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·I Pyykko, J Zou

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