PMID: 6398592Oct 1, 1984Paper

Experimental leprosy in the armadillo and nude mice: comparative histobacteriology and ultrastructure

Acta Leprologica
P RavisseC C Guelpa-Lauras

Abstract

In last 14 years, armadillo has proved an ideal animal model for studying experimental leprosy and mass production of Mycobacterium leprae. However recently a number of groups working with nude mice have claimed its ability as a better experimental model as far as leprosy research and production of leprosy bacilli is concerned. We therefore decided to compare experimental M. leprae infection of both armadillo and nude mice. We compared the degree of infection as well as the physiological and morphological state of proliferating bacteria by histobacteriological and electron microscopic studies. Histobacteriological studies of the infected nude mice showed that the highest number of acid-fast bacilli (AFB) was present in the leprome formed at the site of inoculation, the foot-pad, but often the morphological index (MI) was low. A bacillary diffusion was observed, however the internal organs did not show extensive lesions and contained few AFB with a still lower MI. Similarly the AFB present in the nodes were few in number, formed smaller globi than those formed in the foot-pad, and were essentially non-solid staining bacilli with a lower MI. In the armadillo on the other hand, lesions were extensive and apparent in the internal o...Continue Reading

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