Experimental melanin-induced uveitis: experimental model of human acute anterior uveitis

Ophthalmic Research
Justine R SmithKeryn A Williams

Abstract

Experimental melanin-protein-induced uveitis (EMIU), which is also known as experimental autoimmune anterior uveitis, was first described in 1993 by Broekhuyse et al. This experimental uveitis may be induced in certain inbred and outbred rat strains by immunization with bovine ocular melanin. The inflammation shares clinical features with human acute anterior uveitis. The duration of the first episode is approximately 1 month. Spontaneous recovery to a near normal clinical state is the rule, but multiple recurrences are common. Slit-lamp biomicroscopic examination reveals a florid anterior-chamber reaction, with formation of a retro-iridal empyema, fibrin clots and posterior synechiae. At a microscopic level, leukocytic infiltration is first observed in the anterior uvea. Although this tissue remains the site of maximum inflammation throughout an attack, in severe cases, limbitis, vitritis and choroiditis are also observed. Abrogation of EMIU occurs after treatment with anti-CD4 antibody, indicating that the uveitis is controlled by CD4-positive T cells. Several research groups have used EMIU to investigate various aspects of the pathogenesis of acute anterior uveal inflammation, including the participation of different leukocy...Continue Reading

Citations

Feb 6, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bharati MattaNalini S Bora
May 14, 2020·Current Eye Research·Dan-Ning HuJodi Sassoon
Feb 23, 2019·American Journal of Ophthalmology·Amit K ReddyMina B Pantcheva
Jul 16, 2009·Current Opinion in Obstetrics & Gynecology
Oct 16, 2021·American Journal of Ophthalmology·Matias SoiferVictor L Perez

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