Experimental Methods to Inform Diagnostic Approaches for Painful TMJ Osteoarthritis

Journal of Dental Research
M M SperryEric J Granquist

Abstract

Temporomandibular joint (TMJ) osteoarthritis (OA) is a degenerative disease of the joint that can produce persistent orofacial pain as well as functional and structural changes to its bone, cartilage, and ligaments. Despite advances in the clinical utility and reliability of the Diagnostic Criteria for Temporomandibular Disorders, clinical tools inadequately predict which patients will develop chronic TMJ pain and degeneration, limiting clinical management. The challenges of managing and treating TMJ OA are due, in part, to a limited understanding of the mechanisms contributing to the development and maintenance of TMJ pain. OA is initiated by multiple factors, including injury, aging, abnormal joint mechanics, and atypical joint shape, which can produce microtrauma, remodeling of joint tissues, and synovial inflammation. TMJ microtrauma and remodeling can increase expression of cytokines, chemokines, and catabolic factors that damage synovial tissues and can activate free nerve endings in the joint. Although studies have separately investigated inflammation-driven orofacial pain, acute activity of the trigeminal nerve, or TMJ tissue degeneration and/or damage, the temporal mechanistic factors leading to chronic TMJ pain are un...Continue Reading

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Citations

Jul 2, 2020·Oral Diseases·Oscar Gabriel Castaño-JoaquiMario Fernando Muñoz-Guerra
Mar 30, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Romain NicotFeng Chai
Apr 2, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meagan E ItaBeth A Winkelstein

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Methods Mentioned

BETA
lavage
scraping
biopsy
biopsies

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