Experimental mild traumatic brain injury induces functional alteration of the developing hippocampus.

Journal of Neurophysiology
Zhe Yu, B Morrison

Abstract

It is estimated that approximately 1.5 million Americans suffer a traumatic brain injury (TBI) every year, of which approximately 80% are considered mild injuries. Because symptoms caused by mild TBI last less than half an hour by definition and apparently resolve without treatment, the study of mild TBI is often neglected resulting in a significant knowledge gap for this wide-spread problem. In this work, we studied functional (electrophysiological) alterations of the neonatal/juvenile hippocampus after experimental mild TBI. Our previous work reported significant cell death after in vitro injury >10% biaxial deformation. Here we report that biaxial deformation as low as 5% affected neuronal function during the first week after in vitro mild injury of hippocampal slice cultures. These results suggest that even very mild mechanical events may lead to a quantifiable neuronal network dysfunction. Furthermore, our results highlight that safe limits of mechanical deformation or tolerance criteria may be specific to a particular outcome measure and that neuronal function is a more sensitive measure of injury than cell death. In addition, the age of the tissue at injury was found to be an important factor affecting posttraumatic defi...Continue Reading

References

Dec 1, 1988·The Journal of Trauma·J F Kraus, P Nourjah
Jul 1, 1971·Experimental Neurology·J A Kiernan, D R Pettit
Aug 1, 1980·Pediatric Clinics of North America·R C RaphaelyD A Bruce
Oct 13, 1994·Nature·H Kamiya, R S Zucker
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Apr 1, 1993·Current Opinion in Neurobiology·D G Amaral
Jan 15, 1993·Brain Research. Developmental Brain Research·P A BuchsD Muller
Jan 15, 1993·Brain Research. Developmental Brain Research·D MullerL Stoppini
Mar 1, 1997·Journal of Neurophysiology·C CollinM Segal
Nov 5, 1997·Trends in Neurosciences·B H GähwilerS M Thompson
Jan 1, 1998·The New England Journal of Medicine·J F AnnegersW A Rocca
Jun 13, 1998·Brain Research. Developmental Brain Research·J R VillablancaD A Hovda
Oct 7, 1998·Journal of Neurosurgery·R BullockH F Young
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D PohlC Ikonomidou
May 8, 2000·Journal of Neuroscience Research·T M ReevesJ T Povlishock
Jun 17, 2000·Trends in Neurosciences·A M Thomson
Jul 6, 2000·Journal of Neuroscience Methods·Z XiangP J Bergold
Oct 18, 2000·Seizure : the Journal of the British Epilepsy Association·J F Annegers, S P Coan
Nov 4, 2000·Journal of Neurotrauma·R RaghupathiT K McIntosh
Nov 29, 2001·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·A F Cronin
Jan 5, 2002·Annals of Neurology·V SanthakumarI Soltesz
Jul 12, 2002·Annals of Neurology·Harvey S LevinJeffrey E Max
Jul 13, 2002·The Surgical Clinics of North America·Cynthia L Beaulieu
Nov 19, 2002·Critical Reviews in Biomedical Engineering·W Goldsmith
Apr 5, 2003·Journal of Neurotrauma·Mayumi L Prins, David A Hovda
Jul 10, 2003·Brain Injury : [BI]·Harvey S Levin
Aug 20, 2003·The Journal of Comparative Neurology·John C FialaKristen M Harris
Sep 10, 2003·The Journal of Physiology·Fumiko Mori-KawakamiTomoyuki Takahashi
Apr 29, 2004·Nature Neuroscience·György Buzsáki
Apr 30, 2004·Journal of Neurotrauma·Chang-Qing KaoLeslie S Satin
Jun 15, 2004·Brain Pathology·Ramesh Raghupathi

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Citations

Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Chris KaoPeter Konrad
Jun 20, 2013·Neural Computation·Vladislav Volman, Laurel J Ng
May 3, 2011·Annual Review of Biomedical Engineering·Barclay MorrisonMartin L Yarmush
Oct 14, 2011·Annals of Biomedical Engineering·Tapan P PatelDavid F Meaney
Jun 1, 2012·Acta neurochirurgica·Hans von HolstSvein Kleiven
Nov 16, 2010·Clinics in Sports Medicine·David F Meaney, Douglas H Smith
Sep 29, 2015·Journal of Neurotrauma·Edward W Vogel IiiBarclay Morrison Iii
Jan 30, 2015·Biomechanics and Modeling in Mechanobiology·Woo Hyeun Kang, Barclay Morrison
Dec 18, 2014·Journal of Neurotrauma·Woo Hyeun KangBarclay Morrison
Sep 23, 2014·Biomechanics and Modeling in Mechanobiology·Woo Hyeun Kang, Barclay Morrison
Sep 15, 2016·Scientific Reports·Nasya M SturdivantKartik Balachandran
Apr 4, 2017·Experimental Neurology·Edward W VogelBarclay Morrison
Oct 11, 2012·Einstein·Israel Figueiredo JúniorGlaucia Macedo de Lima
Mar 2, 2016·ASN Neuro·Angeliki M NikolakopoulouIryna M Ethell
Sep 10, 2017·Reviews in the Neurosciences·Francisco Estrada-RojoLuz Navarro
Jan 5, 2014·Journal of Biomechanical Engineering·David F MeaneyCameron Dale Bass
Dec 22, 2019·Annals of Biomedical Engineering·Edward W VogelBarclay Morrison
Dec 24, 2018·BMC Systems Biology·F Anthony San LucasYin Liu
Nov 30, 2018·Forensic Sciences Research·Huiyan SunLuyang Tao
Jul 24, 2021·Advanced Materials·Emilie DauzonThomas D Anthopoulos

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