PMID: 15224864Jul 1, 2004Paper

Experimental model for investigating trans-mucosal gas exchanges in the middle ear of the rat

Acta Oto-laryngologica
Romain E KaniaP Tran Ba Huy

Abstract

The total pressure in the middle ear depends on the air composition of this gas pocket, i.e. on gas exchanges occurring through either the Eustachian tube (ET) or mucosa. The aim of this study was to develop an experimental model to investigate the exclusive role of trans-mucosal gas exchanges in the middle ear (ME). Both tympanic membranes of 20 Sprague-Dawley rats were punctured under general anesthesia. Rats were divided into two equal groups. Group 1 had no ET obstruction. In Group 2, the ET was blocked, after velar incision, by cauterization and application of cyanoacrylate glue into the lumen. One open transparent glass tube containing a droplet of colored water was placed horizontally and connected hermetically to each ear canal. The ME was then flushed with room air through the tube. Variations in ME gas volume were measured by reading the displacement of the liquid droplet in the horizontal tube. The kinetics of variations in gas volume between groups were displayed and statistically compared using a two-sided t-test. The pattern of variations in ME gas volume with time was similar in the two groups. Both were characterized by a decrease with three phases and an elimination rate of approximately 0.152 +/- 0.026 microl/...Continue Reading

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Citations

Oct 8, 2005·Surgical and Radiologic Anatomy : SRA·Andrei P TimoshenkoJean-Michel Prades
May 26, 2006·Journal of the Association for Research in Otolaryngology : JARO·Yael MarcusohnAmos Ar
Feb 13, 2008·Medicinski pregled·Branislava M MajstorovićMilan M Gajić
Oct 30, 2009·Acta Oto-laryngologica·Hans Wilhelm PauJacob Sadé
Jun 20, 2006·Respiratory Physiology & Neurobiology·Amos ArRomain E Kania
Nov 1, 2005·Hearing Research·Ji-Ping LiPhilippe Herman
May 23, 2016·Biological cybernetics·Ole Næsbye LarsenKenneth Kragh Jensen
Jun 8, 2007·The Review of Scientific Instruments·Joris J J DirckxJohan R M Aerts
Sep 15, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·J Fredrik Grimmer, Dennis S Poe
Jul 26, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Udi CinamonTal Marom
Apr 24, 2018·BioMed Research International·Letícia Petersen Schmidt RositoSady Selaimen da Costa
Jul 15, 2006·Journal of Applied Physiology·Romain E KaniaAmos Ar

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