PMID: 9194532Jun 1, 1997Paper

Experimental model of short-time exercise-induced preconditioning in POAD patients

Angiology
P L CapecchiT Di Perri

Abstract

Regular physical exercise improves walking performance in patients affected with peripheral obliterative arterial disease (POAD). The mechanisms underlying the phenomenon are still controversial. In order to verify the hypothesis that physical conditioning of lower limbs on a treadmill and ischemic preconditioning of the heart could share some biological aspects, 14 POAD subjects underwent a training program on the treadmill consisting of five repeated submaximal exercises at five-minute and two-hour intervals preceding the maximal tolerance test. Moreover, a protocol with two daily submaximal walking exercises over one week was also performed. Pain-free and total walking distance were measured before and after they performed the program. Moreover, plasma levels of adenosine and adenosine triphosphate (ATP) were measured and polymorphonuclear (PMN) leukocyte activity was studied together with rheologic parameters. Pain-free distance was prolonged by 15.4% and 14.3%, and total distance was prolonged by 23.1% and 26.9%, in the exercises with five-minute and two-hour intervals, respectively. After one week of daily exercises, the onset of pain and the end of the test were delayed by 24% and 43.7%, respectively. An improvement in b...Continue Reading

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Citations

May 3, 2000·The British Journal of Surgery·K H TanP R Edwards
Dec 13, 2002·The New England Journal of Medicine·Kerry J StewartAlan T Hirsch
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Bing SunJun-Ichi Kambayashi
Nov 29, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Shingo SakamotoSatoshi Takeshita
Dec 2, 2004·Sports Medicine·Andrew C Bulmer, Jeff S Coombes
Dec 11, 2007·Journal of the Neurological Sciences·Israel SteinerItzhak Wirguin
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Peter Whittaker, Karin Przyklenk
Jun 5, 2007·Orvosi hetilap·Anna Landi, István Jassó
Feb 24, 2001·Vascular Medicine·F L PasiniT D Perri
Jan 1, 1997·Vascular Medicine·P L CapecchiT Di Perri

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