Abstract
Implementation of an experimental model to compare cartilage MR imaging by means of histological analyses. MRI was obtained from 4 patients expecting total knee replacement at 1.5 and/or 3T prior surgery. The timeframe between pre-op MRI and knee replacement was within two days. Resected cartilage-bone samples were tagged with Ethi-pins to reproduce the histological cutting course. Pre-operative scanning at 1.5 T included following parameters for fast low angle shot (FLASH: TR/TE/FA=33 ms/6 ms/30 degrees, BW=110 kHz, 120 mm x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness) and double echo steady state (DESS: TR/TE/FA=23.7 ms/6.9 ms/40 degrees, BW=130 kHz, 120 x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness). At 3T, scan parameters were: FLASH (TR/TE/FA=12.2 ms/5.1 ms/10 degrees, BW=130 kHz, 170 x 170 mm FOV, 320 x 320, 0.5mm slice-thickness) and DESS (TR/TE/FA=15.6 ms/4.5 ms/25 degrees, BW=200 kHz, 135 mm x 150 mm FOV, 288 x 320 matrix, 0.5mm slice-thickness). Imaging of the specimens was done the same day at 1.5 T. MRI (Noyes) and histological (Mankin) score scales were correlated using the paired t-test. Sensitivity and specificity for the detection of different grades of cartilage degeneration were assessed. I...Continue Reading
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