Experimental model to evaluate in vivo and in vitro cartilage MR imaging by means of histological analyses

European Journal of Radiology
Bernd BittersohlA Cavallaro

Abstract

Implementation of an experimental model to compare cartilage MR imaging by means of histological analyses. MRI was obtained from 4 patients expecting total knee replacement at 1.5 and/or 3T prior surgery. The timeframe between pre-op MRI and knee replacement was within two days. Resected cartilage-bone samples were tagged with Ethi-pins to reproduce the histological cutting course. Pre-operative scanning at 1.5 T included following parameters for fast low angle shot (FLASH: TR/TE/FA=33 ms/6 ms/30 degrees, BW=110 kHz, 120 mm x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness) and double echo steady state (DESS: TR/TE/FA=23.7 ms/6.9 ms/40 degrees, BW=130 kHz, 120 x 120 mm FOV, 256 x 256 matrix, 0.65 mm slice-thickness). At 3T, scan parameters were: FLASH (TR/TE/FA=12.2 ms/5.1 ms/10 degrees, BW=130 kHz, 170 x 170 mm FOV, 320 x 320, 0.5mm slice-thickness) and DESS (TR/TE/FA=15.6 ms/4.5 ms/25 degrees, BW=200 kHz, 135 mm x 150 mm FOV, 288 x 320 matrix, 0.5mm slice-thickness). Imaging of the specimens was done the same day at 1.5 T. MRI (Noyes) and histological (Mankin) score scales were correlated using the paired t-test. Sensitivity and specificity for the detection of different grades of cartilage degeneration were assessed. I...Continue Reading

References

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Citations

Jun 8, 2013·Journal of Magnetic Resonance Imaging : JMRI·Christoph ZilkensBernd Bittersohl
Feb 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Vanessa A LukasDavid A Reiter
Jun 2, 2009·The Lancet Oncology·Colleen M CostelloeNaoto T Ueno

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