Experimental models and mechanisms of immune deficiencies of nutritional origin

Food Additives and Contaminants
J P Revillard, G Cozon

Abstract

The complex interactions between nutrition, infection and immunity are still poorly understood and the precise role of each factor is difficult to ascertain. Infection itself induces profound metabolic alterations resulting in negative nitrogen balance. Protein energy malnutrition, whatever its origin, results in an immune deficiency characterized by impaired delayed cutaneous hypersensitivity, low production of lymphokines, low T cell counts, decreased T cell responses to specific or non specific mitogenic stimuli. Serum immunoglobulin levels are normal or elevated and antibody responses to most vaccines are normal or slightly altered. Secretory IgA levels, number of IgA plasma cells in jejunal mucosa and specific IgA antibody levels are depressed. Neutrophil chemotaxis and serum opsonic activity are normal but bacterial killing capacity is markedly reduced. C3 levels are usually reduced as a consequence of low hepatic synthesis and increased consumption but most other complement proteins remain within the normal range. Such alterations of immunological parameters can be induced by malnutrition itself but they are commonly observed in populations also exposed to a heavy load of infectious agents from birth. Various types of im...Continue Reading

References

Jan 1, 1983·Journal of Pediatric Gastroenterology and Nutrition·R D Ronnlund, R M Suskind

❮ Previous
Next ❯

Citations

Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ChanB R Bloom
Oct 5, 2015·Preventive Veterinary Medicine·Kate SawfordJenny-Ann L M L Toribio
Jul 26, 2002·Artificial Organs·R Vanholder, R Peleman
Nov 1, 1993·The Journal of Pathology·J S LyraW Savino
Aug 25, 2018·PLoS Biology·Jimena Barbeito-AndrésPatricia Pestana Garcez
Jan 18, 2020·Science Advances·J Barbeito-AndrésP P Garcez
May 20, 2020·Eating and Weight Disorders : EWD·Alberto Rodríguez-QuirogaMarina Díaz-Marsá

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.