PMID: 9546914Jan 1, 1996Paper

Experimental models of chronic lower extremity arterial occlusive disease: lessons for drug development

Vascular Medicine
C D Nicholson

Abstract

Peripheral vascular disease is the result of chronic vascular insufficiency. As the vascular insufficiency of the lower limbs progressively deteriorates, the condition progresses from intermittent claudication (pain upon exercise) to pain at rest and gangrene. In very severe cases amputation of the leg may be necessary. Whilst dieting, cessation of smoking and physical exercise all beneficially affect the progression of the disorder, the available drug therapy is of limited benefit. Very effective pharmacological agents capable of alleviating the symptoms of chronic peripheral vascular disease have not been developed. In order to mimic the vascular insufficiency of intermittent claudication, an animal model was developed in rats. This involves short-term and long-term 6-10 weeks ligation of the femoral artery of the rat. As demonstrated using measurements of hindlimb skeletal muscle, blood flow, pO2, metabolism and function, a model of intermittent claudication was produced. Using this model, the beneficial effects of physical training was demonstrated. Physical training induced an increase in blood flow and a greater capacity for aerobic metabolism in the partially ischaemic skeletal muscle. The effect of vasodilators has also...Continue Reading

References

Dec 28, 1976·Pflügers Archiv : European journal of physiology·C SteinhagenI Hosselmann
Jun 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·D SørlieN K Johnsrud
Nov 30, 1976·European Journal of Clinical Investigation·A C BylundT Scherstén
Jul 1, 1992·Trends in Pharmacological Sciences·D Escande, I Cavero
Apr 1, 1991·European Journal of Vascular Surgery·J A Dormandy, G D Murray
Jul 15, 1990·Annals of Internal Medicine·K Radack, R J Wyderski
Jul 1, 1985·The American Journal of Physiology·M L JenningsK W Cook
Oct 1, 1971·Journal of Applied Physiology·M C ConradJ B Garrett
Feb 1, 1970·Journal of Clinical Pathology·H B BurmesterG I Horsfield
Jan 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·S Zetterquist
Jan 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Obert
May 1, 1983·Pflügers Archiv : European journal of physiology·H ReichmannD Pette
Mar 1, 1981·The American Journal of Physiology·K SahlinE Hultman
May 1, 1982·The Physician and Sportsmedicine·John A HallNathan Pritikin

❮ Previous
Next ❯

Citations

Nov 2, 2011·Acta Cirúrgica Brasileira·Carlos Eli PiccinatoEdwaldo Edner Joviliano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.