PMID: 18209919Jan 23, 2008Paper

Experimental models of hepatectomy and liver regeneration using newborn and weaning rats

Clinics
Ana Cristina Aoun TannuriEvandro Sobroza de Mello

Abstract

Liver regeneration is a complex process that has not been completely elucidated. The model most frequently used to study this phenomenon is 70% hepatectomy in adult rats; however, no papers have examined this effect in developing animals. The aims of the present study were: 1) to standardize two models of partial hepatectomy and liver regeneration in newborn suckling and weaning rats, and 2) to study the evolution of remnant liver weight and histological changes of hepatic parenchyma on the days that follow partial hepatectomy. Fifty newborn and forty-four weaning rats underwent 70% hepatectomy. After a midline incision, compression on both sides of the upper abdomen was performed to exteriorize the right medial, left medial and left lateral hepatic lobes, which were tied inferiorly and resected en bloc. The animals were sacrificed on days 0 (just after hepatectomy), 1, 2, 3, 4 and 7 after the operation. Body and liver weight were determined, and hepatic parenchyma was submitted to histological analysis. Mortality rates of the newborn and weaning groups were 30% and 0%, respectively. There was a significant decrease in liver mass soon after partial hepatectomy, which completely recovered on the seventh day in both groups. Newbo...Continue Reading

Citations

Jun 24, 2015·BioMed Research International·Yu-Wen Chung-DavidsonWeiming Li
Sep 25, 2014·Acta Cirúrgica Brasileira·Widlani Sousa MontenegroIgor Furlan Cella
Jun 29, 2018·Frontiers in Pharmacology·Kateryna UspenskaMaryna Skok

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