Experimental models of hepatic fibrosis: a review

Seminars in Liver Disease
H TsukamotoS W French

Abstract

No experimental model reproduces exactly human liver fibrosis by etiology. Nonetheless, each of the models reviewed in this article has served to enhance our understanding of pathogenetic mechanisms of liver fibrosis. There have been important common findings derived from several different models. The best example is the role of Ito cells in liver fibrogenesis. Involvement of Ito cells was consistently seen in the experimental models regardless of whether the fibrogenic stimulus was nutritional, hepatotoxic, or immunologic. Cellular and molecular mechanisms of Ito cell activation have begun to be explored in different models. Another example is the role of TGF beta in liver fibrogenesis. In both murine schistosomiasis model and Tsukamoto-French rat model, TGF beta was shown to be closely associated with fibrogenesis. With both in vitro and in vivo experimental approaches using cellular and molecular techniques, the experimental model of liver fibrosis will continue to provide data on the pathogenetic mechanisms of liver fibrogenesis. Future genetic and molecular approaches may allow development animal models with liver fibrosis that is inducible and genetically similarity to that of man.

Citations

Mar 3, 2011·Digestive Diseases and Sciences·John Carl HoefsBernard Joseph Ilagan
Dec 31, 2003·Biomaterials·Daniel Palmes, Hans-Ullrich Spiegel
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Jinsil SeongKyung Sik Kim
Feb 5, 2003·The International Journal of Biochemistry & Cell Biology·Beatrice ArezziniConcetta Gardi
Mar 3, 2007·The Journal of Clinical Investigation·John P Iredale
Apr 30, 2011·BMC Gastroenterology·Orhan TarcinNurdan Tözün
Jun 12, 2012·Proteome Science·Xiaofang JiaLijun Zhang
Nov 28, 2013·Fibrogenesis & Tissue Repair·Christian LiedtkeRalf Weiskirchen
Aug 30, 2007·Critical Reviews in Therapeutic Drug Carrier Systems·Kun Cheng, Ram I Mahato
Aug 26, 2011·World Journal of Hepatology·Cathy C MooreLaura W Schrum
Jun 3, 2014·BMC Gastroenterology·Tarak K ChhedaVenkataranganna V Marikunte
Nov 7, 2014·Mediators of Inflammation·Sura Wanessa Santos RochaChristina Alves Peixoto
Jul 2, 2008·Journal of Gastroenterology·Natalie J Török
Dec 16, 2000·Clinical and Experimental Pharmacology & Physiology·C G BrandãoJ Pedrazzoli
Dec 17, 2008·Digestive Diseases and Sciences·Georgios GribilasStamatios E Theocharis
Feb 27, 2009·Digestive Diseases and Sciences·Haralabos C KarantonisStamatios E Theocharis
Jan 1, 1992·Pharmacology & Therapeutics·M Rojkind
Dec 1, 1996·Scandinavian Journal of Gastroenterology·J Wu, P A Norton
Mar 25, 2004·Drug and Chemical Toxicology·Anna Maria BassiGiorgio Nanni
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Svegliati BaroniA Benedetti
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·P Greenwel
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H LouisJ Devière
Mar 27, 2012·Experimental and Molecular Pathology·Joan OlivaFawzia Bardag-Gorce
Feb 25, 2014·Science China. Life Sciences·QianQian ZhaoLiJun Zhang

❮ Previous
Next ❯

Related Concepts