Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

Journal of Clinical Medicine
Maria Giuliana Vannucchi, Stefano Evangelista

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pathogenesis of IBS is only partially understood, a main role has been attributed to psychosocial stress of different origin. Animal models such as neonatal maternal separation, water avoidance stress and wrap restraint stress have been developed as psychosocial stressors in the attempt to reproduce the IBS symptomatology and identify the cellular mechanisms responsible for the disease. The study of these models has led to the production of drugs potentially useful for IBS treatment. This review intends to give an overview on the results obtained with the animal models; to emphasize the role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies.

References

Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Feb 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M GuéL Buéno
Apr 15, 1999·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Y TachéJ Rivier
Feb 29, 2000·British Journal of Pharmacology·M ToulouseL Buéno
Mar 29, 2000·Progress in Brain Research·P E SawchenkoA Ericsson
Sep 30, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M O'SullivanC A O'Morain
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·E A MayerS V Coutinho
Jun 11, 2002·Gastroenterology·Vinton S ChadwickIan Wilson
Jun 11, 2002·Gastroenterology·Emeran A Mayer, Stephen M Collins
Oct 30, 2003·Neuroscience Letters·Geneviève-Anne Gaudreau, Victor Plourde
Dec 4, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A RosztóczyL Buéno
Jul 2, 2004·Journal of Neurochemistry·Ekaterini ChatzakiDimitri E Grigoriadis
Dec 14, 2004·The Journal of Comparative Neurology·Sumei LiuJackie D Wood
Mar 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sylvie BradesiEmeran A Mayer
Apr 9, 2005·Annals of the New York Academy of Sciences·Eric W FishMichael J Meaney
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O WeltingG E Boeckxstaens
Jun 15, 2007·Reproductive Toxicology·Moshe SzyfMichael Meaney
Feb 1, 2008·European Journal of Pharmacology·Dorota Kakol-PalmErik Lindström
Mar 1, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muriel LaraucheJames A McRoberts
Apr 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C RosenbergerE R Gizewski
Aug 27, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H EutameneL Bueno
Mar 6, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Peter R StregeGianrico Farrugia
Jan 1, 2009·Digestive Diseases·Peter Holzer, Ulrike Holzer-Petsche
May 15, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M LacknerM D Sitrin
Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
May 10, 2011·Current Gastroenterology Reports·Marjorie M WalkerNicholas J Talley
May 18, 2011·Experimental Neurology·Muriel LaraucheYvette Taché

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Citations

Apr 5, 2019·Molecular Neurobiology·Diana SerraTeresa C P Dinis
Dec 13, 2019·Nature Communications·Nikolai RakhilinXiling Shen
Sep 29, 2020·Journal of Biomedical Science·Lesha Pretorius, Carine Smith
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José Antonio UrangaRaquel Abalo
Feb 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mengjuan LinBaoping Yu
Nov 21, 2020·International Journal of Molecular Sciences·Yoshiyuki Mishima, Shunji Ishihara
Apr 4, 2021·International Journal of Molecular Sciences·Isabella GiganteMaria Notarnicola
Apr 4, 2021·International Journal of Molecular Sciences·Guglielmina ChimientiFrancesco Russo
Jun 11, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed ElbadawiThomas Efferth
Nov 26, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Li ZhaoHongfang Li

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Methods Mentioned

BETA
biopsies
biopsy

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