Experimental models of Parkinson's disease

Nature Reviews. Neuroscience
M F Beal

Abstract

Research into the pathogenesis of Parkinson's disease has been rapidly advanced by the development of animal models. Initial models were developed by using toxins that specifically targeted dopamine neurons, the most successful of which used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a toxin that causes parkinsonism in man. More recently, the identification of alpha-synuclein mutations as a rare cause of Parkinson's disease has led to the development of alpha-synuclein transgenic mice and Drosophila. Here, I discuss the merits and limitations of these different animal models in our attempts to understand the physiology of Parkinson's disease and to develop new therapies.

References

Jul 1, 1991·Journal of Neurochemistry·P ChanD Di Monte
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·I Bodis-WollnerY Samson
Jul 1, 1990·Journal of the Neurological Sciences·B R BloemJ W Langston
Oct 1, 1986·Annals of Neurology·L S FornoG A Ricaurte
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Dec 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K W LangeP Riederer
Aug 1, 1994·Journal of Neurophysiology·H BergmanM R DeLong
Feb 1, 1993·Journal of Neurochemistry·Y S Lau, M M Mouradian
Mar 21, 1996·Nature·D M GashG A Gerhardt
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·S PrzedborskiT M Dawson
Sep 25, 1995·European Journal of Pharmacology·A BenazzouzC Gross
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·L S Forno
Sep 1, 1996·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·P A TrimmerJ P Bennett
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·J P SteinerP D Suzdak
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·N TakahashiG R Uhl
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·D OffenO Bernard
May 26, 1998·Journal of Neuropathology and Experimental Neurology·P F GoodC W Olanow
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Muralikrishnan, K P Mohanakumar
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Oct 15, 1998·The New England Journal of Medicine·P LimousinA L Benabid
Oct 15, 1998·The New England Journal of Medicine·A E Lang, A M Lozano

❮ Previous
Next ❯

Citations

Apr 1, 2003·Annals of Neurology·M Flint Beal
Aug 25, 2004·Neurotoxicity Research·Sylvie GélinasMaria-Grazia Martinoli
Oct 27, 2004·Cell and Tissue Research·Andreas Schober
Sep 15, 2004·Cell and Tissue Research·Jörg B Schulz, Björn H Falkenburger
Feb 6, 2008·Journal of Neural Transmission·G LinazasoroJ A Ruiz Ortega
Aug 23, 2011·Journal of Neural Transmission·Dénes ZádoriLászló Vécsei
Mar 31, 2011·Amino Acids·M Flint Beal
Jan 11, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Márcio Ferreira DutraMatilde Achaval
Mar 18, 2006·Apoptosis : an International Journal on Programmed Cell Death·V D Nair
Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·Tomohiro Nakamura, Stuart A Lipton
Mar 6, 2009·Journal of Inherited Metabolic Disease·K J Skvorak
Jan 18, 2013·Cellular and Molecular Neurobiology·Raymond FarahZaher Arraf
Nov 19, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Amarnath GuptaMaryann E Martone
Apr 9, 2005·Neuropharmacology·Nevena RaicevicVladimir Trajkovic
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·G Díaz-VélizJ Segura-Aguilar
Aug 14, 2003·Trends in Pharmacological Sciences·Hui Ming GaoJau Shyong Hong
Aug 30, 2002·Neurotoxicology and Teratology·Michael A Collins, Edward J Neafsey
Sep 19, 2003·Neurobiology of Disease·Karen L O'MalleyWilliam Holtz
Aug 21, 2003·Trends in Molecular Medicine·Shun ShimohamaTakashi Taniguchi
Sep 29, 2009·Inorganic Chemistry·Mark S Jackson, Jennifer C Lee
Aug 12, 2005·Cell Death and Differentiation·Z GuS A Lipton
Jan 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·M Emdadul HaqueDavid S Park
Mar 10, 2005·The Journal of Biological Chemistry·Jason CallioCharleen T Chu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.