PMID: 11912671Mar 27, 2002Paper

Experimental models of partial lesion of rat spinal cord to investigate neurodegeneration, glial activation, and behavior impairments

The International Journal of Neuroscience
Gerson ChadiVânia Canterucci Gomide

Abstract

The article demonstrates two experimental models of spinal cord partial injury in rats: a contuse model promoted by the NYU impactor system and a partial hemitransection model achieved by a stereotaxic-positioned adjustable wire knife. By means of a defined impact weight (10 g) and a digital optical potentiometer linked to a computer, the impactor transferred and registered a moderate or a severe contusion to the rat spinal cord at a low thoracic level after dropping the weight from distances of 25 mm and 50 mm, respectively, to the dorsal surface of the exposed dura spinal cord. Impact curve was calculated and the parameters of the trauma, like impact velocity, cord compression distance and cord compression rates were obtained in order to demonstrate trauma severity. To promote partial hemitransection, rats were positioned in a spinal cord unit of a stereotaxic apparatus and lesion was made with the adjustable wire knife spatially oriented. By means of a computerized infrared motion sensor-home cage activity monitor and a noncomputerized evaluation of motor behavior using the inclined plane and the motor score of Tarlov tests, behavior was analyzed in an acute period postlesion. Rats were sacrificed and spinal cords were proce...Continue Reading

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Citations

Apr 25, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Fatih BayrakliHamit Zafer Kars
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M MyersJ B Kerr
Jan 25, 2011·Journal of Neuroscience Research·Araceli Diaz-RuizCamilo Ríos
Jun 2, 2010·Brain Research·Michele Schultz Ramos AndradeGerson Chadi
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jinger do Carmo CunhaGerson Chadi
Sep 21, 2018·Neural Regeneration Research·Mayara Ferraz de MenezesRégis Gemerasca Mestriner

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