Experimental models of temporary normothermic liver ischemia

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
H U Spiegel, R Bahde

Abstract

Hepatic ischemia/reperfusion injury has so far been investigated in various experimental models. A clinical transfer of experimental results is, however, problematic because of anatomical and physiological differences and also the inevitable simplification of experimental work. The choice of model must therefore be adapted to the clinical question to be answered. The simplest procedure for inducing normothermic ischemia is to clamp the hepatoduodenal ligament. Models that do not avert portal congestion are regarded as unsuitable. Our current understanding of the pathogenesis of ischemia/reperfusion injury depends mainly on studies whose authors have investigated either global liver ischemia with a portocaval shunt, spleen transposition and in the isolated perfused system, or partial ischemia. This review is a critical examination of various approaches to the study of normothermic hepatic ischemia in experimental animals.

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Citations

Mar 14, 2009·Cellular and Molecular Neurobiology·Zdeno PirnikAlexander Kiss
Mar 14, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Rafael Omar GiovanardiAntonio Nocchi Kalil
Jul 24, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jianjian ZhangQiang Xia
Mar 31, 2009·Transplantation Proceedings·S FrimanD S Delbro
Jun 9, 2009·The Journal of Surgical Research·Imam H Shaik, Reza Mehvar
Jun 23, 2009·The Journal of Surgical Research·Rafael Omar GiovanardiAntonio Nocchi Kalil
Nov 14, 2006·Transplantation Proceedings·J HeimanD Delbro
Jan 22, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mahmoud Abu-AmaraBrian R Davidson
Apr 11, 2015·BioMed Research International·Raffaele CursioJean Gugenheim
Feb 2, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jessica P OtisHannah V Carey
Feb 13, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dora CatréMaria F Lopes
Oct 8, 2008·European Journal of Clinical Investigation·D PevniA Weinbroum

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