PMID: 8964762Mar 1, 1996Paper

Experimental modification of rat pituitary growth hormone cell function during and after spaceflight

Journal of Applied Physiology
W C HymerP K Lane

Abstract

Space-flown rats show a number of flight-induced changes in the structure and function of pituitary growth hormone (GH) cells after in vitro postflight testing (W. C. Hymen, R. E. Grindeland, I. Krasnov, I, Victorov, K. Motter, P. Mukherjee, K. Shellenberger, and M. Vasques. J. Appl. Physiol. 73, Suppl.: 151S-157S, 1992). To evaluate the possible effects of microgravity on growth hormone (GH) cells themselves, freshly dispersed rat anterior pituitary gland cells were seeded into vials containing serum +/- microM hydrocortisone (HC) before flight. Five different cell preparations were used: the entire mixed-cell population of various hormone-producing cell types, cells of density < 1.071 g/cm3 (band 1), cells of density > 1.071 g/cm3 (band 2), and cells prepared from either the dorsal or ventral part of the gland. Relative to ground control samples, bioactive GH released from dense cells during flight was reduced in HC-free medium but was increased in HC-containing medium. Band 1 and mixed cells usually showed opposite HC-dependent responses. Release of bioactive GH from ventral flight cells was lower; postflight responses to GH-releasing hormone challenge were reduced, and the cytoplasmic area occupied by GH in the dense cells ...Continue Reading

Citations

Aug 24, 2000·Journal of Applied Physiology·G E McCallV R Edgerton
Dec 13, 2005·Journal of Applied Physiology·A J BigbeeV R Edgerton
Sep 14, 1999·Journal of Applied Physiology·G E McCallV R Edgerton
Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Gianni BioloFelice Strollo
Feb 10, 2004·Journal of Applied Physiology·K L GosselinkV R Edgerton
May 9, 1998·Journal of Applied Physiology·K L GosselinkV R Edgerton
Jan 21, 2000·Journal of Applied Physiology·K L GosselinkV R Edgerton
Feb 14, 1998·Journal of Applied Physiology·G E McCallV R Edgerton
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H VandenburghJ Lemaire
Dec 7, 2019·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Wesley C HymerWilliam J Kraemer

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