Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid

Veterinary Research Communications
S D StoevE E Creppy

Abstract

Mycotoxic nephropathy was induced in 18 young pigs by diets contaminated with strains of Aspergillus ochraceus containing ochratoxin A (OTA) and penicillic acid (PA) at levels corresponding to those naturally encountered in animal feeds in Bulgaria. Haematological and biochemical parameters, as well as the morphological and ultrastructural changes in various internal organs, and especially in the kidneys, were examined at different stages of development of the disease. A mottled surface of the kidneys was only seen in pigs exposed to a mouldy diet containing 180 ppb OTA for 3 months, but microscopic lesions, as well as changes in various haematological and biochemical parameters, were observed in all groups exposed to the same mouldy diet containing only 90 or 180 ppb OTA. Histological examination showed two types of change: degenerative changes affecting the epithelial cells of the proximal tubules, which predominated at the initial stage, and proliferative changes in the interstitium, which predominated at the later stage of the disease. Telangiectasis and lymph stasis were also seen, as well as degenerative changes in the capillary endothelium. The characteristic renal lesions were similar to those observed in spontaneous ca...Continue Reading

Citations

Apr 3, 2012·Bulletin of Environmental Contamination and Toxicology·Jelka PleadinMate Brstilo
Jun 19, 2013·Critical Reviews in Food Science and Nutrition·Stoycho D Stoev
Nov 6, 2013·Toxins·Maja Segvić KlarićMaja Peraica
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Mar 28, 2009·International Journal of Molecular Sciences·Stoycho D Stoev
Mar 16, 2011·Critical Reviews in Toxicology·Sofia Cancela DuarteCeleste Matos Lino
Apr 20, 2017·Toxins·Firdevs MorOzlem Ozmen
May 4, 2004·Environmental Health Perspectives·Kati HuttunenMaija-Riitta Hirvonen
Sep 17, 2009·Analytical and Bioanalytical Chemistry·Kristian Fog NielsenJens Christian Frisvad
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Annie Pfohl-Leszkowicz
Sep 16, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·S D StoevP A Steenkamp
Feb 1, 2010·Mycotoxin Research·Stoycho D StoevIordan Petkov
Oct 11, 2014·PloS One·Szilamér FerencziBalázs Kriszt
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Mar 31, 2009·International Journal of Molecular Sciences·Dragan MilićevićSasa Janković
Jul 12, 2018·Applied Microbiology and Biotechnology·Magnus Hallas-MøllerJens Christian Frisvad
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Nolwenn HymeryEmmanuel Coton
Nov 19, 2005·Chemico-biological Interactions·Diana RingotYvan Larondelle
Jun 23, 2020·Toxicon : Official Journal of the International Society on Toxinology·Stoycho D Stoev
Apr 7, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N AoudiaY Larondelle

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