Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.

The American Journal of Pathology
Mark DunleavyDavid C Henshall

Abstract

Hippocampal sclerosis is a common pathological finding in patients with temporal lobe epilepsy, including children, but a causal relationship to early-life seizures remains in question. Neonatal status epilepticus in animals can result in neuronal death within the hippocampus, although macroscopic features of hippocampal shrinkage are not evident at adulthood. Here, we examined electrophysiological and pathological consequences of focally evoked status epilepticus triggered by intra-amygdala microinjection of kainic acid in postnatal day 10 rat pups. Neonatal status epilepticus resulted in extensive neuronal death in the ipsilateral hippocampal CA1 and CA3 subfields and hilus, as assessed by DNA fragmentation and Fluoro-Jade B staining 72 hours later. The contralateral hippocampus was not significantly damaged. Histopathology at P55/P65 revealed unilateral hippocampal sclerosis (grade IV, modified Wyler/Watson scale) comprising >50% CA1 and CA3 neuron loss and astrogliosis. Additional features included hydrocephalus ex vacuo, modest dentate granule cell layer widening, and altered neuropeptide Y immunoreactivity indicative of synaptic rearrangement. Hippocampal atrophy was also evident on magnetic resonance imaging. Depth elect...Continue Reading

References

Jun 30, 1978·Brain Research·S M WuertheleK E Moore
Jul 1, 1992·Postgraduate Medical Journal·A Hopkins
Feb 21, 1992·Brain Research. Developmental Brain Research·C E StafstromG L Holmes
Jan 14, 1994·Brain Research. Developmental Brain Research·D Chang, T Z Baram
Dec 16, 1997·Brain : a Journal of Neurology·G W MathernW J Peacock
Feb 18, 1998·Neuroscience·K ThompsonC Wasterlain
Jul 1, 1997·Reviews in the Neurosciences·M S Kelley, O Steward
Oct 7, 1998·Epilepsy Research·A PitkänenT Salmenperä
Feb 12, 1999·Brain Research. Developmental Brain Research·E M MontgomeryJ G Csernansky
Sep 8, 2000·Annals of Neurology·E R PerezT Deonna
Sep 15, 2000·Current Opinion in Neurology·U Felderhoff-Mueser, C Ikonomidou
Sep 22, 2000·Epilepsia·H Jürgen WenzelP A Schwartzkroin
Oct 12, 2000·Annals of Neurology·R SankarC G Wasterlain
Jul 30, 2002·Progress in Brain Research·Claude G WasterlainYukioyoshi Shirasaka
Sep 11, 2002·Trends in Neurosciences·Sarit Avishai-ElinerTallie Z Baram
Jan 29, 2003·Neurology·C BoctiL Carmant
Mar 17, 2004·Trends in Pharmacological Sciences·John W OlneyChrysanthy Ikonomidou
Jun 26, 2004·The European Journal of Neuroscience·Hana KubováAsla Pitkänen
Sep 24, 2004·Lancet Neurology·Sheryl R HautSolomon L Moshé
Oct 19, 2004·Lancet Neurology·Christian E ElgerMartin Kurthen
Jan 18, 2006·Journal of Neuropathology and Experimental Neurology·Arjune SenSanjay M Sisodiya
Feb 1, 2006·Brain : a Journal of Neurology·Céline DubéTallie Z Baram
Feb 14, 2006·Lancet·Renzo Guerrini
Apr 11, 2006·Epilepsy Currents·Claude G Wasterlain
Apr 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HeinrichCarola A Haas
Aug 18, 2006·Lancet Neurology·Miquel Raspall-ChaureRod C Scott
Nov 2, 2006·The International Journal of Neuropsychopharmacology·Hans BouwmeesterJan M van Ree
Nov 18, 2006·Lancet Neurology·Yehezkel Ben-Ari, Gregory L Holmes

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Citations

Jul 8, 2011·Pediatric Radiology·Nadja KadomWilliam D Gaillard
Jan 4, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mahmood MotamediElham Rahimian
Aug 24, 2010·Seminars in Pediatric Neurology·Karthik RajasekaranHoward P Goodkin
Apr 7, 2015·Epilepsy & Behavior : E&B·David C Henshall, Tobias Engel
Sep 19, 2012·The Journal of Comparative Neurology·Jeffrey HelgagerJames O McNamara
Apr 23, 2014·CNS Neuroscience & Therapeutics·Guillaume MesuretDavid C Henshall
Nov 5, 2013·Neuroscience and Biobehavioral Reviews·Maxime Lévesque, Massimo Avoli
May 31, 2014·Neurobiology of Disease·Ozlem AkmanAristea S Galanopoulou
Jul 6, 2016·Epilepsia·Conner D ReynoldsJoaquin N Lugo
Aug 4, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Mayumi MatsufujiAkihisa Mitsudome
Jan 24, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M B MironovT T Batysheva
Aug 20, 2019·Neuropharmacology·Gaetano TerroneAnnamaria Vezzani
Jan 22, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Marius GasserCelina von Stülpnagel

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