PMID: 8952023Nov 1, 1996Paper

Experimental neosporosis in pregnant ewes and their offspring

Veterinary Pathology
M M McAllisterR H Stobart

Abstract

Six groups of six pregnant ewes each were inoculated with 170,000 or 1,700,000 tachyzoites of Neospora caninum on gestation day 65, 90, or 120. All ewes seroconverted, and none showed signs of illness other than abortion. Regardless of the inoculum dose, all ewes inoculated on gestation day 65 aborted; ewes inoculated on gestation day 90 aborted, gave birth to weak lambs, or gave birth to clinically normal lambs; and all ewes inoculated on gestation day 120 gave birth to clinically normal lambs. Using an immunohistological procedure that stains bradyzoites, we observed protozoal cysts in brains of 11 of 29 (38%) aborted fetuses, in one of four (25%) weak lambs, and in seven of 18 (39%) clinically normal lambs. Cysts were not observed in extraneural tissues from two clinically normal lambs that had cysts in the brain. No evidence of infection was observed in tissues of five ewes examined using an immunohistological procedure that stains N. caninum tachyzoites and bradyzoites. Multifocal nonsuppurative encephalitis was observed in 46 of 51 (90%) aborted, weak, or clinically normal lambs. Cerebral necrosis, dystrophic mineralization, and meningitis were also commonly identified in live and aborted lambs (even when severely autolyz...Continue Reading

References

Aug 1, 1992·Journal of Comparative Pathology·H OginoK Kawashima
Jul 1, 1992·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B C BarrP A Conrad
Jul 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J P Dubey, D S Lindsay
Sep 1, 1990·Veterinary Pathology·B C BarrP A Conrad
Jul 1, 1989·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J P Thilsted, J P Dubey
Sep 1, 1989·The Journal of protozoology·C A Speer, J P Dubey
Mar 1, 1995·Australian Veterinary Journal·J G BoultonJ P Dubey
Jan 21, 1995·The Veterinary Record·A HarmelinJ P Dubey
Oct 1, 1994·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M J YaegerP Leslie-Steen
Oct 1, 1994·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L W WoodsK W Sverlow
Apr 1, 1994·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B C BarrP A Conrad
Oct 1, 1993·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R A ColeB L Blagburn
Jul 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M M McAllisterM D Salman
Oct 1, 1994·New Zealand Veterinary Journal·R N ThorntonJ Evans

❮ Previous
Next ❯

Citations

Nov 27, 1999·International Journal for Parasitology·A HemphillA Hehl
Dec 23, 1999·International Journal for Parasitology·C Björkman, A Uggla
Dec 2, 1996·Veterinary Parasitology·J P Dubey, D S Lindsay
May 29, 1999·Veterinary Parasitology·W R JolleyR A Wills
Aug 24, 1999·Veterinary Parasitology·J P Dubey
Jul 21, 2005·New Zealand Veterinary Journal·A Antony, N B Williamson
Jun 24, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L JensenV Bille-Hansen
Jun 7, 2000·Australian Veterinary Journal·M P Reichel
Mar 8, 2014·Experimental Parasitology·Thierry Monney, Andrew Hemphill
Aug 30, 2008·Tropical Animal Health and Production·Tatiana Evelyn Hayama UenoRodrigo Martins Soares
Jun 14, 2014·Parasitology·Julio BenavidesLuis M Ortega-Mora
Jan 13, 2004·The Veterinary Quarterly·Th A M Elsinghorst
Aug 28, 2015·The Journal of Parasitology·David S Lindsay
Jun 9, 2009·Veterinary Parasitology·J F WestonP R Kenyon
Jul 4, 1998·Journal of Comparative Pathology·D BuxtonE A Innes
Sep 24, 2004·International Journal for Parasitology·J P DubeyC E Greene
Jul 1, 1997·Journal of Comparative Pathology·D BuxtonE A Innes
Feb 21, 2002·The Journal of Veterinary Medical Science·Yoshifumi NishikawaHideyuki Nagasawa
Mar 10, 2001·Parasite Immunology·D BuxtonE A Innes
Jan 23, 2003·The Journal of Parasitology·Ryan O'HandleyJ P Dubey
Apr 16, 2003·American Journal of Veterinary Research·R M O'HandleyJ P Dubey
May 29, 1998·The Veterinary Record·M R OwenA J Trees
Oct 8, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Nicola MeixnerMatthias Müller
Mar 5, 2018·International Journal for Parasitology. Drugs and Drug Resistance·Roberto Sánchez-SánchezLuis Miguel Ortega-Mora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.