Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial

Diabetologia
Malin NilssonJørgen Rungby

Abstract

Previous studies have demonstrated a relationship between cognitive impairment and hypoglycaemia (<3 mmol/l). This study hypothesised that non-severe insulin-induced hypoglycaemia reduces cognitive function in individuals with type 2 diabetes. In this randomised crossover study, 25 participants with type 2 diabetes attended two experimental visits with hyperinsulinaemic glucose clamping: one hypoglycaemic clamp (plasma glucose 3.0 ± 0.2 mmol/l) and one euglycaemic clamp (plasma glucose 6.0 ± 0.2 mmol/l). Participants were eligible if their diabetes was treated with diet or glucose-lowering medications (except sulfonylureas or insulin), age was 35-70 years, BMI was 23-35 kg/m2 and HbA1c was below 75 mmol/mol (9%). Cognitive function was assessed with a neurocognitive test battery measuring verbal memory, executive function, sustained attention and psychomotor speed. From the examined cognitive domains, a global cognition score was constructed estimating global cognition. A measurement for psychomotor speed was selected as the primary outcome. Participants and people assessing the outcomes were blinded to group assignment. Cognitive performance was impaired during hypoglycaemia with a mean score in the primary outcome test, Symbo...Continue Reading

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Citations

Jun 18, 2020·BMJ Open Diabetes Research & Care·Simon R HellerApril D Taylor
Sep 26, 2020·Frontiers in Psychology·Qian ZhaoWeiwen Wang
Jan 7, 2021·Journal of Diabetes Science and Technology·Giada AcciaroliHalis Kaan Akturk
Dec 10, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xue LvQing Yu
Nov 3, 2020·Clinical and Translational Medicine·Chengkang HeZhiming Zhu
May 25, 2021·Acta Diabetologica·Lorenzo Piemonti

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