Experimental Oesophagostomum bifurcum in monkeys

Journal of Helminthology
M L EberhardA M Polderman

Abstract

OESOPHAGOSTOMUM BIFURCUM: larvae, cultured from human stools collected in northern Ghana, were used to establish experimental infections in monkeys. A patent infection was established in a rhesus monkey (Macaca mulatta) and this infection was used to generate larvae to inoculate additional monkeys. In all, 17 animals were inoculated. Thirteen of 15 animals developed antibodies to the infection between 19 and 62 days post inoculation (PI); two animals had a positive response before inoculation. Four of ten animals developed patent infections between 88 and 134 days and passed eggs in the faeces. Egg shedding was consistent in only one animal, but at low levels of one or two eggs per 2 mg direct smear, and extended over a 400 day period. In the other three animals, egg shedding was sporadic and of only 2-4 weeks duration. In seven animals necropsied between 19 and 22 days PI, one to 17 early fourth-stage larvae were recovered from nodules in the bowel wall; in an eighth animal examined at 314 days, six immature adult worms (early fifth stage) were recovered from nodules in the bowel wall. The morphological features and growth of these recovered larvae are described. Three animals were inoculated with larvae that had been dried fo...Continue Reading

References

Jun 1, 1992·Annals of Tropical Medicine and Parasitology·H P KrepelA M Polderman
Apr 1, 1992·The American Journal of Tropical Medicine and Hygiene·H P Krepel, A M Polderman
Mar 1, 1991·The American Journal of Tropical Medicine and Hygiene·A M PoldermanP Gigase
Jul 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M PoldermanJ P Rotmans
Dec 1, 1995·Parasitology Today·A M Polderman, J Blotkamp

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Citations

Mar 25, 2011·Journal of the Royal Society, Interface·Andrew J J MacintoshMichael A Huffman
Mar 20, 2010·PLoS Neglected Tropical Diseases·Sabrina KriefJacques Guillot
Dec 20, 2005·Tropical Medicine & International Health : TM & IH·Lisette van LieshoutA M Polderman
Feb 17, 2015·The Journal of Parasitology·William D HelenbrookChristopher M Whipps
Jun 12, 2014·International Journal for Parasitology. Parasites and Wildlife·Andrew P StringerWayne L Linklater

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