Experimental one year ochratoxin A toxicosis in pigs

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
S D StoevP G Mantle

Abstract

Mild mycotoxic nephropathy was induced in 6 pigs by a diet containing ochratoxin A at 800 ppb, several times higher than that naturally encountered in some feed for pig production in Bulgaria. The nephropathy was expressed only as slightly hypertrophied kidneys with a faintly mottled surface, discernible at the end of the experiment to a skilled observer but probably not recognisable in routine slaughterhouse processing. Histological examination showed two types of changes: degenerative - affecting epithelial cells in some proximal tubules of pigs after 6 months, and proliferative changes in the interstitium which predominated after 1 year of exposure to ochratoxin A. Telangiectasis and lymph stasis were rarely seen. The renal lesions were similar to those described for classical mycotoxic porcine nephropathy formerly encountered in Denmark, but they were rather different from the porcine nephropathy which occurs spontaneously in Bulgaria. Measurement of ochratoxin A in serum provided analytical values complementary to feed intake and with similar concentration values. It also showed both accumulation with time, from 3 months to 6 months (approximately 1 ppm), and a 2-fold range of values within a group eating from a common fee...Continue Reading

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Citations

Aug 13, 2011·Mycotoxin Research·Hussaini Anthony MakunAdamu Y Kabiru
Sep 16, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·S D StoevP A Steenkamp
Jun 19, 2013·Critical Reviews in Food Science and Nutrition·Stoycho D Stoev
Jun 4, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Zein AbbasSiegfried Wolffram
Mar 28, 2009·International Journal of Molecular Sciences·Stoycho D Stoev
Mar 31, 2009·International Journal of Molecular Sciences·Dragan MilićevićSasa Janković
Apr 1, 2010·Toxins·Lalini Reddy, Kanti Bhoola
Jul 1, 2010·Toxins·Gianni BattaconeGiuseppe Pulina
Mar 4, 2005·Critical Reviews in Toxicology·Evelyn O'Brien, Daniel R Dietrich
Feb 8, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Stoycho D StoevYves-Jacques Schneider
Dec 26, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Zheqian ZhangKehe Huang
Apr 7, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N AoudiaY Larondelle
Jul 17, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Amy L BrownPeter G Mantle
Dec 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alexandra H HeussnerEvelyn O'Brien
Dec 17, 2008·Molecular Nutrition & Food Research·Angela Mally, Wolfgang Dekant
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Annie Pfohl-Leszkowicz
Sep 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A H HeussnerE O'Brien
Apr 25, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ana MiljkovicPeter G Mantle
Feb 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Peter G Mantle
Dec 30, 2014·Free Radical Biology & Medicine·Fang GanKehe Huang
Jul 25, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A VettorazziA López de Cerain
Jun 14, 2017·International Journal of Environmental Research and Public Health·Ahmad Alshannaq, Jae-Hyuk Yu
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jul 21, 2007·International Journal of Cancer. Journal International Du Cancer·Fabio GalvanoMaja Peraica
Feb 1, 2010·Mycotoxin Research·Stoycho D StoevIordan Petkov
Apr 23, 2013·Mycotoxin Research·H Marina MartinsFernando Bernardo
Nov 1, 2017·Frontiers in Public Health·Carina LadeiraOrish Ebere Orisakwe
Mar 2, 2021·Frontiers in Veterinary Science·Lan ZhengSung Woo Kim
Aug 27, 2021·Toxins·Agnieszka Tkaczyk, Piotr Jedziniak

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