PMID: 7090758Jun 1, 1982Paper

Experimental osteoarthritis in the rabbit: comparison of different periods of repeated immobilization

Acta Orthopaedica Scandinavica
T Videman


The objective of this study was to compare the degree of osteoarthritis caused by different periods of repeated immobilization and mobilization. Existing knowledge of the pathogenic factors causing osteoarthritis is deficient, but it is well known that long-term immobilization produces degenerative joint changes. In this experimental study it is shown that short repetitive periods of immobilization also induce osteoarthritis. The results can be summarized as follows: immobilization, periodic or continuous, over more than 30 days will lead to progressive osteoarthritis. The range of motion after periodic immobilization depends more on the total immobilization time than on the duration of either the immobilization or mobilization periods. Even an immobilization period of 4 days had a cumulative effect in producing osteoarthritis. An interval of 4 weeks between immobilization periods did not prevent immobilization from causing osteoarthritis. It can be assumed that all situations which lead to the immobilization of a joint can cause osteoarthritis changes. Radiology, photography, and histology all showed some degree of degenerative changes also in the contralateral non-immobilized knee.


Aug 1, 1978·Acta Orthopaedica Scandinavica·I EronenJ E Michelsson
Sep 1, 1975·Clinical Orthopaedics and Related Research·A Finsterbush, B Friedman
May 1, 1973·Clinical Orthopaedics and Related Research·A Finsterbush, B Friedman
Apr 1, 1970·British Journal of Plastic Surgery·P L Field, J T Hueston


Jan 1, 1985·International Orthopaedics·A Nachemson
Jul 1, 1991·Calcified Tissue International·J E BadurskiJ Pawlica
Sep 1, 1992·Journal of Pharmacological and Toxicological Methods·H A al-Haboubi, I J Zeitlin
Jun 23, 2011·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Tomonori BabaYuichiro Maruyama
Jan 14, 2005·Annals of the Rheumatic Diseases·P JonesN Lynskey
Apr 1, 1992·Annals of the Rheumatic Diseases·I Meyer-Carrive, P Ghosh
Jun 1, 1994·Annals of the Rheumatic Diseases·K P Pritzker
May 1, 1997·Annals of the Rheumatic Diseases·E VingårdH Malchau
Aug 7, 2012·Journal of Basic and Clinical Physiology and Pharmacology·Breanna Willeford
Dec 10, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Hui-qin Yang, Li-rong Chen
Jan 1, 1996·The Journal of Orthopaedic and Sports Physical Therapy·C A ReynoldsL J Tillman
Jun 1, 1990·Acta Orthopaedica Scandinavica·S Z HeC Bünger
Jan 1, 1983·Scandinavian Journal of Rheumatology·H Vanharanta
Jan 1, 1985·Scandinavian Journal of Rheumatology·I Eronen, T Videman
May 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C S CarlsonC P Jerome
Apr 5, 2007·Journal of Photochemistry and Photobiology. B, Biology·Mohammad BayatAghdas Bayat
Feb 11, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S R TorelliI Q Grassioto
Nov 1, 1987·Clinical Biomechanics·T Videman
Jan 11, 2014·Journal of Physical Therapy Science·Taro MatsuzakiMasahiro Hoso
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S R TorelliA J Crocci
Mar 1, 1993·The American Journal of Sports Medicine·E VingårdC Hogstedt
Jan 19, 2008·Medicine and Science in Sports and Exercise·Ajit M W ChaudhariThomas P Andriacchi
Feb 25, 1998·The American Journal of Sports Medicine·E VingårdH Malchau
Jul 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Hui YangXiao-Shuang Huang
Nov 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Shuang HuangYong-Hui Yang
Nov 2, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tamás OláhHenning Madry

Related Concepts

Hypokinesia, Experimental
Knee Joint
Osteoarthrosis Deformans
Bone Structure of Tibia

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.