PMID: 2101486Sep 1, 1990Paper

Experimental ovine salmonellosis (Salmonella abortusovis): pathogenesis and vaccination

Research in Microbiology
P PardonP Berthon

Abstract

Salmonella enterica subsp. enterica ser. Abortusovis, a sheep-adapted serotype, causes a contagious disease. Abortion is the major symptom and the main source of contamination. Research on this ovine disease may aid farmers, but may also contribute to comparative biological knowledge. Innate resistance partly controlled by the Ity locus, increased resistance to reinfection and humoral and T-cell-mediated immunity were observations gained with a murine model. In ewes, abortion regularly occurs following subcutaneous challenge carried out from the third month of gestation onwards. This ovine model was used to evaluate prevention methods for Salmonella Abortusovis infection. One subcutaneous injection of a live attenuated lyophilized vaccine containing a selected streptomycin-independent reverse mutant was shown to protect ewes against abortion and excretion of Salmonella Abortusovis. This vaccine could be administered simultaneously with other commercial live vaccines such as Brucella melitensis Rev. 1 vaccine. In sheep, application of the vaccine to the conjunctiva (an easy, individual and hygienic route of mucosal vaccination) was followed by lymph node bacterial colonization and a serological response without local or general ...Continue Reading

Citations

Jan 15, 2008·Oecologia·Maryline PiozEmmanuelle Gilot-Fromont
Jul 1, 1997·Veterinary Immunology and Immunopathology·J S RothelP R Wood
Jun 27, 2000·FEMS Microbiology Letters·S UzzauS Rubino
Jun 19, 1998·Veterinary Microbiology·A BourgogneM Pépin
Dec 1, 2005·New Zealand Veterinary Journal·H LiJ Wagner
Mar 1, 2012·Animal Reproduction Science·P I Menzies
Apr 21, 2006·Veterinary Microbiology·Anna Maria DionisiGiovanni Pezzotti
Dec 7, 2005·Journal of Leukocyte Biology·Michel BonneauIsabelle Schwartz-Cornil
Nov 5, 2002·FEMS Microbiology Reviews·Helen S GarmoryRichard W Titball
Dec 9, 2021·Current Microbiology·Giulia AmaglianiEnrica Omiccioli

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