PMID: 12527322Jan 16, 2003Paper

Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic saline

European Journal of Pain : EJP
T Graven-NielsenAlf Sollevi

Abstract

Deep tissue pain can be related to reduced muscle blood flow, which comprises the metabolic demand under muscle work. The tissues and receptors involved in nociception after ischaemic muscle contractions are not known. The concentration of adenosine is increased after ischaemic contractions and might act as an algesic substance. In 15 subjects, adenosine, hypertonic saline (algesic), and isotonic mannitol (placebo) were infused into the tibialis anterior muscle and compared with the pain caused by ischaemic contractions. The muscle pain intensity (visual analogue scale; VAS), distribution, and quality were assessed. Pressure pain thresholds were recorded to assess the deep tissue sensitivity. Adenosine did not induce more pain than the placebo. The maximal VAS score after hypertonic saline and ischaemic contractions was higher compared with adenosine/placebo infusions. The duration and area of pain were significantly increased after hypertonic saline infusions compared with ischaemic contractions. Higher scores on the McGill pain questionnaire were given to the "stabbing", "burning", "heavy", and "exhausting" word categories after ischaemic contractions, and "cramping" was rated higher during hypertonic saline-induced muscle pa...Continue Reading

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Citations

Apr 28, 2006·Experimental Brain Research·William GibsonThomas Graven-Nielsen
Sep 25, 2008·Experimental Brain Research·Helle AndersenThomas Graven-Nielsen
Nov 8, 2003·Current Pain and Headache Reports·Thomas Graven-Nielsen, Lars Arendt-Nielsen
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Jan 25, 2013·The Clinical Journal of Pain·Michail KoutrisMachiel Naeije
Oct 29, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Line Bay SørensenThomas Graven-Nielsen

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