PMID: 1576638Apr 1, 1992Paper

Experimental pain in human temporal muscle induced by hypertonic saline, potassium and acidity

Cephalalgia : an International Journal of Headache
K Jensen, M Norup

Abstract

The study was aimed at developing a reference model for experimental pain and tenderness in the human temporal muscle by the local injection of hypertonic saline, potassium chloride and acidic phosphate buffer, using isotonic saline as control. The design was randomized and double-blind. Twenty healthy subjects had 0.2 ml test solution injected into one temporal muscle and saline into the other. Following each injection, pain was rated on a 10-point ordinal scale and pressure-pain thresholds were measured every minute for 10 min by a pressure algometer. Hypertonic saline (n = 11) and potassium chloride (n = 12) induced significantly more pain than isotonic saline (ANOVA, p less than 0.0001). Compared to control injections, hypertonic saline and potassium chloride induced a significant reduction in pressure-pain threshold (ANOVA, p less than 0.0001 and p less than 0.05). Forty-eight percent of the injections led to the referral of pain most often to the jaws. A positive correlation between the relative occurrence of referred pain and pain intensity was observed (p less than 0.001) as was a negative correlation between the decrease in pressure-pain threshold and pain intensity (p less than 0.05).

References

Sep 1, 1991·Cephalalgia : an International Journal of Headache·K JensenI Jansen
Dec 1, 1987·Cephalalgia : an International Journal of Headache·M Langemark, J Olesen
Jan 1, 1969·Acta Orthopaedica Scandinavica·O Lindahl
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Citations

Jan 14, 2009·Experimental Brain Research·S Mense
Aug 29, 2012·Experimental Brain Research·Troy K RubinVaughan G Macefield
Sep 22, 2000·Current Review of Pain·P Svensson, L Arendt-Nielson
Sep 1, 1995·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·P Svensson, L Arendt-Nielsen
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May 6, 2006·Cephalalgia : an International Journal of Headache·P T Schmidt-HansenF W Bach
May 16, 2002·European Journal of Oral Sciences·Jens C TürpQiguo Rong
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Oct 24, 2007·The Journal of Headache and Pain·A Kemal Erdemoglu, Ayhan Varlibas
Aug 17, 1999·Cephalalgia : an International Journal of Headache·R Jensen
May 1, 1996·Cephalalgia : an International Journal of Headache·R Jensen, J Olesen
May 3, 2003·European Journal of Pain : EJP·Helen SlaterThomas Graven-Nielsen
Feb 26, 2003·European Journal of Pain : EJP·Hanne MørkRigmor Jensen
Feb 9, 2010·British Journal of Pharmacology·N VergnolleN W Bunnett
Dec 20, 2005·Pain·William GibsonThomas Graven-Nielsen
Dec 13, 2006·Pain·Peter T Schmidt-HansenFlemming W Bach
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Oct 14, 2006·Journal of Applied Physiology·D FallaT Graven-Nielsen
Feb 19, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yahya I AsiriBernard A MacLeod

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