Experimental pain sensitivity in subjects with major depression: Many pain complaints without hypersensitivity

International Journal of Psychiatry in Medicine
Murielle GirardDominique Malauzat

Abstract

Patients with major depression frequently complain of pain, but conflicting data exist concerning their changes in pain sensitivity. This study aimed at comparing the sensitivity to moderate controlled pain between subjects presenting a major depressive episode (isolated and recurrent depressive episodes or a bipolar disorder), controls, and subjects with schizophrenia from a previous study. Pain sensitivity was assessed obtaining the visual analog scale (VAS) rating for the application of a 160 kPa pre-fixed pressure (fpVAS), the pressure corresponding to a VAS score of 3, and the time required to achieve a VAS score of 3 during ischemia induction. The effects of depression intensity, alexithymia, current and past general pain, and of six weeks of antidepressant treatment on fpVAS were investigated. The results did not differ significantly between the depressed groups and the controls, without any effect of depression intensity. Presence of long-lasting pain and current pain felt on the day of testing correlated with fpVAS. The subjects of the depressed group were less sensitive than subjects with schizophrenia. FpVAS was significantly lower before and after antidepressant treatment in the subjects presenting clinical improvem...Continue Reading

References

Apr 1, 1989·The Journal of Nervous and Mental Disease·M W OttoR A Yeo
Jan 1, 1973·Psychotherapy and Psychosomatics·P E Sifneos
Mar 1, 1994·Journal of Psychiatric Research·S Lautenbacher, J C Krieg
Nov 15, 1993·Biological Psychiatry·G Adler, W F Gattaz
Oct 28, 1999·The New England Journal of Medicine·G E SimonJ Ormel
Jun 12, 2001·Journal of Psychosomatic Research·G LoasUNKNOWN Réseau INSERM no. 494013
Jan 7, 2003·Archives of General Psychiatry·Maurice M Ohayon, Alan F Schatzberg
Aug 23, 2003·Journal of Psychosomatic Research·Graeme J TaylorJames D A Parker
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jul 6, 2004·L'Encéphale· F fargesPh Jeammet
Sep 21, 2004·Human Psychopharmacology·Jean-Pierre Lépine, Mike Briley
Aug 3, 2005·Pain·Karl-Jürgen BärHeinrich Sauer
Mar 7, 2006·Journal of Affective Disorders·Koen DemyttenaereJordi Alonso
Mar 7, 2007·Annals of Internal Medicine·Kurt KroenkeBernd Löwe
Aug 3, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Stephen M ThielkeJürgen Unützer
Oct 30, 2007·Pharmacotherapy·Michael W Jann, Julian H Slade
Dec 19, 2007·Psychotherapy and Psychosomatics·Glen I Spielmans
Jan 16, 2008·CNS Drugs·Gary McCleane
Apr 18, 2008·Expert Review of Neurotherapeutics·Norbert MüllerHans-Jürgen Möller
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Vladimir Maletic, Charles L Raison
Oct 20, 2009·European Journal of Pain : EJP·Janneke TerhaarKarl-Jürgen Bär
Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Christiane SchwierKarl-Jürgen Bär
Jan 26, 2010·The Journal of Pain : Official Journal of the American Pain Society·Miao ShiFei Luo
Feb 13, 2010·Journal of Psychiatric Research·Maurice M Ohayon, Alan F Schatzberg
Jun 24, 2010·The Journal of Pain : Official Journal of the American Pain Society·Christopher J StarrRobert C Coghill
Sep 8, 2010·The Journal of Clinical Psychiatry·Edith NormandSerge Marchand
Dec 21, 2010·Journal of Affective Disorders·Frank EuteneuerWinfried Rief
Dec 31, 2010·Journal of Clinical Psychopharmacology·Karl-Jürgen BärThomas Weiss
Feb 8, 2011·Comprehensive Psychiatry·Ka-Fai Chung, Kwok-Chu Tso
Mar 19, 2011·Journal of Clinical Pharmacology·Pinky DharmshaktuBhupinder Singh Kalra
May 20, 2011·The Clinical Journal of Pain·Murielle GirardDominique Malauzat
May 28, 2011·Brain : a Journal of Neurology·Christopher J StarrRobert C Coghill
Aug 25, 2011·Current Medicinal Chemistry·A M WaszkielewiczH Marona
Dec 14, 2011·Pain·Marloes M J G GerritsBrenda W J H Penninx
Apr 17, 2012·Neuroscience Letters·Isabella MutschlerIrina A Strigo

❮ Previous
Next ❯

Citations

Jan 13, 2018·International Journal of Psychiatry in Clinical Practice·Ana García-BlancoLorenzo Livianos
May 29, 2019·Issues in Mental Health Nursing·Aude PaquetMurielle Girard
Aug 3, 2017·Issues in Mental Health Nursing·Aude PaquetMurielle Girard

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.