Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristics.

PloS One
Alexander T CiotaLaura D Kramer

Abstract

St. Louis encephalitis virus (SLEV; Flaviviridae, flavivirus) was the major cause of epidemic flaviviral encephalitis in the U.S. prior to the introduction of West Nile virus (WNV) in 1999. However, outbreaks of SLEV have been significantly more limited then WNV in terms of levels of activity and geographic dispersal. One possible explanation for these variable levels of activity is that differences in the potential for each virus to adapt to its host cycle exist. The need for arboviruses to replicate in disparate hosts is thought to result in constraints on both evolution and host-specific adaptation. If cycling is the cause of genetic stability observed in nature and arboviruses lack host specialization, then sequential passage should result in both the accumulation of mutations and specialized viruses better suited for replication in that host. Previous studies suggest that WNV and SLEV differ in capacity for both genetic change and host specialization, and in the costs each accrues from specializing. In an attempt to clarify how selective pressures contribute to epidemiological patterns of WNV and SLEV, we evaluated mutant spectra size, consensus genetic change, and phenotypic changes for SLEV in vivo following 20 sequentia...Continue Reading

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Citations

Oct 3, 2012·PLoS Pathogens·Naomi L ForresterScott C Weaver
Dec 20, 2013·Viruses·Alexander T Ciota, Laura D Kramer
May 1, 2012·BMC Evolutionary Biology·Alexander T CiotaLaura D Kramer
Jan 18, 2012·Journal of Molecular Microbiology and Biotechnology·Isabel S NovellaClaus O Wilke
Mar 20, 2014·The Journal of General Virology·Alexander T CiotaLaura D Kramer
Dec 15, 2012·The Journal of General Virology·Sarah D Smith-TsurkanIsabel S Novella
Apr 1, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Camilo Arias-GoetaAnna-Bella Failloux
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Jan 11, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alexander T CiotaLaura D Kramer
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Oct 27, 2020·Frontiers in Microbiology·Rachel Bellone, Anna-Bella Failloux

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Methods Mentioned

BETA
PCR

Software Mentioned

DNASTAR

Related Concepts