Experimental pig model of clinically relevant wound healing delay by intrinsic factors.

International Wound Journal
Youngjin JungKihwan Han

Abstract

The intrinsic factors associated with delayed wounds are ischaemia, infection, the presence of necrotic tissue and the presence of foreign bodies. This study was designed to create adaptable intrinsic factors induced delayed wound healing model in the pig, similar to clinical conditions. Four pigs were used in this study. Ten 4 × 4 cm fresh full-thickness skin defect wounds were made on the back of each pig. Double-flanged blocks made of silicon, a material that induces foreign body reactions, tissue ischaemia and causes local wound infection, were inserted into half of the wounds (n = 5) and removed at weeks 1, 2 or 3. The other wounds (n = 5) were left open for control purposes. Biopsies were obtained at weeks 1-4 for histological examinations and to evaluate inflammatory cytokines, which included tumour necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6. A Periscan PIM 3 Laser was used to measure degrees of ischaemia. A Visitrak Digital(®) device was used to measure the sizes of unhealed wounds. After 3 weeks, unhealed mean wound sizes were 30·72 ± 3·36 and 2·91 ± 1·51 cm(2) , in the experimental and control groups, respectively. Laser Doppler showed limited perfusion at wound margins in wounds containing silicone block...Continue Reading

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Citations

Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Garazi GainzaRosa Maria Hernandez
Mar 26, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Garazi GainzaManoli Igartua
Dec 4, 2014·Molecular Immunology·Artur SummerfieldMeret E Ricklin
Jan 11, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kiran Kumar ChereddyVéronique Préat
Jul 3, 2016·Journal of Tissue Viability·Woonhyeok JeongDaegu Son
Jan 17, 2019·Anatomia, histologia, embryologia·Maneenooch Khiao InJohanna Plendl
May 21, 2015·ILAR Journal·Max SeatonNicole S Gibran
Jun 10, 2021·Journal of Tissue Viability·Jennifer K ZindleKath M Bogie

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