Experimental pneumococcal meningitis: III. Chemotactic activity in cerebrospinal fluid.

Proceedings of the Society for Experimental Biology and Medicine
C M NolanH N Beaty

Abstract

Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56 degrees and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

Citations

Apr 1, 1979·Annals of Neurology·D J WylerA W Karchmer
Jan 1, 1985·Journal of Neurology·K Felgenhauer, D Kober
Mar 1, 1984·Journal of the Neurological Sciences·G M HochwaldJ Gorelick
Dec 4, 2003·Journal of Neuroimmunology·Petra J G ZwijnenburgA Marceline van Furth
Feb 26, 1998·Immunopharmacology·P F Stahel, S R Barnum
Feb 24, 2006·Infection and Immunity·Petra J G ZwijnenburgA Marceline van Furth
Mar 1, 1978·Journal of Clinical Pathology·B M Greenwood
Jan 1, 1993·Annual Review of Medicine·A R Tunkel, W M Scheld
Feb 1, 1986·Microbial Pathogenesis·E TuomanenA Tomasz
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld

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