Experimental Pseudomonas exotoxin A mediated ocular damage in mouse pups: microscopic observations

Ophthalmic Research
L D HazlettR S Berk


The ocular damage in mouse pups produced by purified Pseudomonas aeruginosa exotoxin A was examined microscopically following toxin A injection beneath the fused eyelid. In contrast to infection, in which lysis of ocular surface epithelium occurs within minutes, toxin A does not induce any lytic changes until 5 h after injection. Additionally, no phagocytic cellular response to toxin A was observed, whereas in infection, this response is seen within 1 h. We conclude that toxin A is not the bacterial extracellular factor responsible for mediating the rapid early destruction of the ocular epithelium allowing bacterial penetration and dissemination.


May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael J Giese, Barry A Weissman
Nov 1, 1990·Antimicrobial Agents and Chemotherapy·F R BurnsJ T Wells

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