Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin

Journal of Vascular Surgery
John E RectenwaldPeter K Henke

Abstract

Pulmonary embolism (PE) is a life-threatening condition that is associated with the long-term sequelae of chronic pulmonary hypertension. Prior experimental work has suggested that post-PE inflammation is accompanied by pulmonary artery intimal hyperplasia. This study evaluated the effect of the thrombus and tested the hypothesis that thrombolytic, antiplatelet, and anticoagulant agents would decrease pulmonary injury. Male Sprague-Dawley rats (n = 267) underwent laparotomy and temporary clip occlusion of the infrarenal inferior vena cava for the formation of endogenous thrombus or placement of an inert silicone "thrombus." Two days later, repeat laparotomy was performed, the clip removed, and the thrombus or silicone plug was embolized to the lungs. The endogenous thrombus group received normal saline, low-molecular-weight heparin (LMWH), tissue plasminogen activator (tPA), or a gIIB/IIIA antagonist (abciximab). Lung tissue was harvested at various times over 21 days and assayed for total collagen, monocyte chemoattractant protein-1 (MCP-1), interleukin-13 (IL-13), and transforming growth factor-beta (TGF-beta). Fixed sections were stained with trichrome for intimal hyperplasia determination and ED-1 monocytes and alpha-actin-...Continue Reading

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Citations

Jul 1, 2009·Irish Journal of Medical Science·S Paredes VilaL Valdes Cuadrado
Sep 16, 2009·The American Journal of Emergency Medicine·Suleyman TurediUtku Ucar
Jun 19, 2007·The Journal of Surgical Research·Nicholas A DewyerPeter K Henke
Jan 1, 2015·Nature Reviews. Disease Primers·Alisa S WolbergNigel Mackman
Oct 26, 2018·Journal of Cellular and Molecular Medicine·Zhenkun LiLing Li
Jun 20, 2012·Journal of Biophotonics·Susan M Daly, Martin J Leahy
Nov 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elaheh MirhadiAmirhossein Sahebkar
May 1, 2021·Journal of Clinical Medicine·Leszek GromadzińskiMarta Majewska

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