Experimental rayless goldenrod (Isocoma pluriflora) toxicosis in goats

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
B L StegelmeierJeffery O Hall

Abstract

Rayless goldenrod (Isocoma pluriflora) sporadically poisons livestock in the southwestern United States. Similarities with white snakeroot (Ageratina altissima) poisoning and nearly identical chemical analyses led early researchers to conclude that tremetol, a mixture of benzofuran ketones, is the rayless goldenrod toxin. The toxicity of these ketone toxins have not been fully characterized nor are the pathogenesis and sequelae of poisoning completely understood. The objective of the current study was to characterize and describe the clinical and pathologic changes of rayless goldenrod toxicity in goats. Fifteen goats were gavaged with rayless goldenrod to obtain benzofuran ketone doses of 0, 10, 20, 40, and 60 mg/kg/day. After 7 treatment days, the goats were euthanized, necropsied, and tissues were processed for microscopic studies. After 5 or 6 days of treatment, the 40-mg/kg and 60-mg/kg goats were reluctant to move, stood with an erect stance, and became exercise intolerant. They had increased resting heart rate, prolonged recovery following exercise, and increased serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and creatinine kinase activities. All treated animals developed skeletal myop...Continue Reading

References

Nov 15, 1973·Biochemical Pharmacology·C H WuT J Mende
Nov 1, 1962·Journal of Medicinal and Pharmaceutical Chemistry·L H ZALKOWE A GRULA
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Monte S WillisDavid G Grenache

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Citations

May 18, 2011·The Veterinary Clinics of North America. Food Animal Practice·Karyn Bischoff, Mary C Smith
May 29, 2016·Research in Veterinary Science·T Z DavisS Buck
Oct 22, 2013·Toxicon : Official Journal of the International Society on Toxinology·T Zane DavisJames A Pfister
Jul 9, 2013·Toxicon : Official Journal of the International Society on Toxinology·T Z DavisJ O Hall
Oct 10, 2020·The Veterinary Clinics of North America. Food Animal Practice·T Zane DavisMichael J Clayton
Jun 19, 2020·Toxicon: X·T Zane DavisStephen T Lee
Feb 3, 2015·Journal of Agricultural and Food Chemistry·T Zane DavisJames A Pfister

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