Experimental reconstruction of an abdominal wall defect with electrospun polycaprolactone-ureidopyrimidinone mesh conserves compliance yet may have insufficient strength

Journal of the Mechanical Behavior of Biomedical Materials
Lucie HympánováJan Deprest

Abstract

Electrospun meshes mimic the extracellular matrix, which may improve their integration. We aimed to compare polycaprolactone (PCL) modified with ureidopyrimidinone (UPy) electrospun meshes with ultra-lightweight polypropylene (PP; Restorelle) reference textile meshes for in vivo compliance. We chose UPy-PCL because we have shown it does not compromise biomechanical properties of native tissue, and because it potentially can be bioactivated. We performed ex vivo biomechanical cyclic loading in wet conditions and in vivo overlay of full-thickness abdominal wall defects in rats and rabbits. Animals were sacrificed at 7, 42 and 54 days (rats; n = 6/group) and 30 and 90 days (rabbits; n = 3/group). Outcomes were herniation, mesh degradation and mesh dimensions, explant compliance and histology. High failure rates prompted us to provide additional material strength by increasing fiber diameter and mesh thickness, which was further tested in rabbits as a biomechanically more challenging model. Compliance was tested in animals without herniation. In both species, UPy-PCL-explants were as compliant as native tissue. In rats, PP-explants were stiffer. Contraction was similar in UPy-PCL and PP-explants. However, UPy-PCL-meshes macroscopic...Continue Reading

Citations

Nov 7, 2019·Biomaterials Science·Matilde PuttiPatricia Y W Dankers
Apr 23, 2019·Current Opinion in Urology·Katerina MackovaJan Deprest
Jun 12, 2021·International Journal of Nanomedicine·Jian LiuRongrong Wang
Dec 6, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·Chantal M DiedrichJan Paul Roovers

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