Experimental reproduction of beak atrophy and dwarfism syndrome by infection in cherry valley ducklings with a novel goose parvovirus-related parvovirus

Veterinary Microbiology
Hao ChenYouxiang Diao

Abstract

Infection of clinically susceptible ducks, including cherry valley and Muscovy ducks, with a novel goose parvovirus (GPV)-related virus (N-GPV) can result in beak atrophy and dwarfism syndrome (BADS). To obtain new insights into the host range and pathogenic potential of this novel waterfowl parvovirus, cherry valley ducklings (n=20) were experimentally infected with N-GPV strain SDLC01. An equal number of ducklings served as uninfected controls. The appearance of clinical signs, histopathological changes, viral shedding, and seroconversion was monitored for 20 days post-infection. Infection status of all ducks was monitored using indirect ELISA, virus neutralization test, nested PCR, clinical indicators, and microscopic examination. Three ducks developed the typical clinical, gross, and histological changes of BADS. By study day 6, the infected ducks had seroconverted to N-GPV. The antibodies raised were neutralizing against the SDLC01 strain in vitro. Here we successfully developed an experimental infection model for studying the pathogenicity and role of N-GPV in BADS.

Citations

Apr 20, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shao WangYou-Quang Cheng
Sep 4, 2016·Veterinary Immunology and Immunopathology·Tian-Fei YuJun-Wei Wang
Aug 16, 2016·Journal of Virological Methods·Xiaoyu NiuYouxiang Diao
Sep 29, 2020·Journal of Veterinary Research·Jie LiuZiqiang Cheng
Feb 21, 2019·BMC Veterinary Research·Jinyue ZhangAnchun Cheng
Jul 10, 2020·Veterinary Research·Ning LiSidang Liu
Nov 25, 2020·Tropical Animal Health and Production·Özlem Kardoğanİnci Başak Müştak
Dec 22, 2020·Frontiers in Veterinary Science·Yudong YangNing Li
Dec 19, 2020·Animals : an Open Access Journal From MDPI·Anna Karolina MatczukAlina Wieliczko

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