Experimental results from the reaction of bromate ion with synthetic and real gastric juices

Toxicology
Jason D KeithGilbert Gordon

Abstract

This study was designed to identify and quantify the effects of reducing agents on the rate of bromate ion reduction in real and synthetic gastric juice. This could be the first element in the sequence of a pharmacokinetic description of the fate of bromate ion entering the organism, being metabolized, and subsequently being tracked through the system to the target cell or eliminated. Synthetic gastric juice containing H+ and Cl- did exhibit reduced bromate ion levels, but at a rate that was too slow for a significant amount of bromate to be reduced under typical stomach retention time conditions. The reaction orders for Cl- and H+ were 1.50 and 2.0, respectively. Addition of the reducing agents hydrogen sulfide (which was shown to be present and quantified in real gastric juice), glutathione, and/or cysteine increased the rate of bromate ion loss. All of the reactions showed significant pH effects. Half-lives as short as 2 min were measured for bromate ion reduction in 0.17 M H+ and Cl- and 10(-4) M H2S. Therefore, the lifetime of bromate ion in solutions containing typical gastric juice concentrations of H+, Cl-, and H2S is 20-30 min. This rate should result in as much as a 99% reduction of bromate ion during its residence in...Continue Reading

Citations

Sep 19, 2009·Biodegradation·Monserrat ChairezReyes Sierra-Alvarez
Jun 16, 2012·Toxicology·Richard J BullBrian S Cummings
Sep 16, 2015·Environmental Science & Technology·Alexandra FischbacherTorsten C Schmidt
Nov 22, 2005·Toxicology·Richard J Bull, Joseph A Cottruvo
Jan 28, 2010·Analytica Chimica Acta·Aleksey N PisarenkoShane A Snyder
Jul 26, 2011·Inorganic Chemistry·Aleksey N PisarenkoDouglas B Mawhinney
Dec 19, 2019·International Journal of Environmental Health Research·Jerry L CampbellHarvey J Clewell

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