PMID: 8960505Nov 1, 1996Paper

Experimental results with endovascular irradiation via a radioactive stent

International Journal of Radiation Oncology, Biology, Physics
A J Carter, J R Laird

Abstract

The objective of this article is to describe the methods used to manufacture a radioactive stent and to review the experimental data on this therapy designed to improve arterial patency rates after stent placement. Surface activation in a cyclotron and ion implantation techniques are used to render commercially available vascular stents radioactive. beta-Particle-emitting stents, most commonly 32P, were employed because of their short half-life (14.3 days) and limited range of tissue penetration (3-4 mm). The function and vascular response to these 32P radioactive stents with varying activities (range 0.14-23 microCi) was evaluated in several animal models of arterial injury and restenosis. In porcine iliac arteries, beta-particle-emitting stents with an initial activity of 0.14 microCi reduced neointimal formation 37% at 28 days after implant. On histology, the neointima consisted of smooth muscle cells and a proteoglycan-rich matrix. Scanning electron microscopy demonstrated complete endothelialization of the stent. beta-Particle-emitting stents with an initial activity of 3-23 microCi inhibited neointimal smooth muscle cell proliferation at 28 days in a porcine coronary restenosis model. The neointima within these high-activ...Continue Reading

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May 17, 2000·Journal of Biomedical Materials Research·P O ZamoraZ H Oster
Sep 19, 2001·Australasian Physical & Engineering Sciences in Medicine·N BoeingM A Ebert
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·A FarbR Virmani
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Sep 22, 1998·Lancet·G E Laramore, K J Stelzer
Oct 7, 2004·Journal of the American College of Cardiology·Robert S SchwartzRenu Virmani

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