Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System

International Journal of Radiation Oncology, Biology, Physics
Annalisa PatriarcaLudovic De Marzi

Abstract

Recent in vivo investigations have shown that short pulses of electrons at very high dose rates (FLASH) are less harmful to healthy tissues but just as efficient as conventional dose-rate radiation to inhibit tumor growth. In view of the potential clinical value of FLASH and the availability of modern proton therapy infrastructures to achieve this goal, we herein describe a series of technological developments required to investigate the biology of FLASH irradiation using a commercially available clinical proton therapy system. Numerical simulations and experimental dosimetric characterization of a modified clinical proton beamline, upstream from the isocenter, were performed with a Monte Carlo toolkit and different detectors. A single scattering system was optimized with a ridge filter and a high current monitoring system. In addition, a submillimetric set-up protocol based on image guidance using a digital camera and an animal positioning system was also developed. The dosimetric properties of the resulting beam and monitoring system were characterized; linearity with dose rate and homogeneity for a 12 × 12 mm2 field size were assessed. Dose rates exceeding 40 Gy/s at energies between 138 and 198 MeV were obtained, enabling u...Continue Reading

Citations

Jul 30, 2019·The British Journal of Radiology·Hakan NystromPetra Witt Nystrom
Jun 28, 2019·Medical Physics·Peter G MaximJing Cai
Nov 7, 2019·The British Journal of Radiology·Andries N Schreuder, Jacob Shamblin
Mar 4, 2020·Molecular Oncology·Claudio FiorinoBen Heijmen
Sep 30, 2020·Journal of Applied Clinical Medical Physics·Christoph SchuyUli Weber
Feb 6, 2020·Frontiers in Oncology·Joseph D WilsonKristoffer Petersson
Sep 10, 2020·International Journal of Molecular Sciences·Jonathan R Hughes, Jason L Parsons
Oct 18, 2020·Medical Physics·Hao GaoJeffery Bradley
Sep 11, 2020·Medical Physics·Michael M FolkertsC Clifton Ling
Jul 30, 2020·Physics in Medicine and Biology·Nolan EsplenMagdalena Bazalova-Carter
Dec 10, 2020·Medical Physics·Michael SnyderDi Yan
May 10, 2020·Seminars in Radiation Oncology·Suparna DuttSamuel Strober
Aug 6, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L De MarziM Vidal
Dec 10, 2020·Physics in Medicine and Biology·Guoliang ZhangHao Peng
Dec 11, 2020·Radiation Research·Ahmed AlanaziJean-Paul Jay-Gerin
Dec 29, 2020·Physics in Medicine and Biology·Alexander BerneBorivoj Vojnovic
Jan 15, 2021·International Journal of Radiation Oncology, Biology, Physics·Mahbubur RahmanDavid J Gladstone
Feb 16, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jörg PawelkeElke Beyreuther
Jan 23, 2021·Medical Physics·Georgios KourkafasJens Heufelder
Feb 12, 2021·Physics in Medicine and Biology·Frank VerhaegenDaniëlle Eekers
Jun 11, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter G MaximBilly W Loo
Jan 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Eric S DiffenderferKeith A Cengel
Mar 7, 2021·Biomedicines·Loredana G MarcuPuthenparampil Wilson
Nov 14, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wei ZouLei Dong
Sep 19, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Simon JollyCarsten Welsch
Sep 22, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Sudharsan SrinivasanJacobus Maarten Schippers
Feb 12, 2021·Physics in Medicine and Biology·Jeppe Brage ChristensenSairos Safai
Mar 30, 2021·Physics in Medicine and Biology·Mohammad RezaeeJohn W Wong
May 21, 2021·Physics in Medicine and Biology·Vaiva KaveckyteJosé M Fernández-Varea
Jun 12, 2021·Frontiers in Oncology·Binwei LinXiaobo Du
May 21, 2021·Physics in Medicine and Biology·Mahbubur RahmanPetr Bruza

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