Aug 16, 1977

Experimental spongy degeneration in calves

Acta Neuropathologica
D Y Cho, H W Leipold


Experimental reproduction and ultrastructural findings of spongy degeneration of the central nervous system of hyperammonemic calves are described. Hyperammonemia was produced by intravenous infusion of ammonium acetate. Histologic findings were stereotyped in all calves and characterized by widespread vacuolation of white and grey matter of the brain spinal cord. Electron microscopy revealed widespread intramyelinic vacuoles, some expansion of extracellular spaces and swollen mitochondria. There were minimal changes in neurons, axons and glia, and little evidence of myelin breakdown. Hyperammonemia may be one of the pathogeneses involved in the CNS spongy degeneration in man and domestic animals effected with hepatocerebral diseases and some hereditary disorders.

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Mentioned in this Paper

Extracellular Space
Canavan Disease
Cell Growth
Brain and Spinal Cord
Electron Microscopy

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