Sep 9, 2011

Experimental strategies for investigating psychostimulant drug actions and prefrontal cortical function in ADHD and related attention disorders

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Kara L AgsterB D Waterhouse


Amphetamine-like psychostimulant drugs have been used for decades to treat a variety of clinical conditions. Methylphenidate (MPH)-Ritalin(R) , a compound that blocks reuptake of synaptically released norepinephrine (NE) and dopamine (DA) in the brain, has been used for more than 30 years in low dose, long-term regimens to treat attention deficit-hyperactive disorder (ADHD) in juveniles, adolescents, and adults. Now, these agents are also becoming increasingly popular among healthy individuals from all walks of life (e.g., military, students) and age groups (teenagers thru senior citizens) to promote wakefulness and improve attention. Although there is agreement regarding the primary biochemical action of MPH, the physiological basis for its efficacy in normal individuals and ADHD patients is lacking. Study of the behavioral and physiological actions of clinically and behaviorally relevant doses of MPH in normal animals provides an opportunity to explore the role of catecholamine transmitters in prefrontal cortical function and attentional processes as they relate to normal operation of brain circuits and ADHD pathology. The goal of ongoing studies has been to: (1) assess the effects of low dose MPH on rodent performance in a w...Continue Reading

Mentioned in this Paper

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Prefrontal Cortex
Catecholamine [EPC]
Synaptic Transmission

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