PMID: 8590788Oct 1, 1995Paper

Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro

Acta Diabetologica
M A TormoJ E Campillo

Abstract

The intestine has a high glycolytic activity, but its metabolic role could be altered in diabetes mellitus. The aim of the present work was to investigate in vivo the glucose retained and the lactate produced by the intestine of normal and diabetic rats and in vitro the effect of different arterial glucose concentrations on glucose utilization and lactate, alanine, and pyruvate production in normal and diabetic rats when the glucose is supplied to the intestine exclusively via the vascular route. In vivo, the normal and diabetic rats retained similar percentages of the arterially supplied glucose (14.7 +/- 2.4, respectively). In vitro, when the preparations were perfused under hyperglycemic conditions, the glucose consumed, as a fraction of the quantity infused, was significantly lower (P < 0.05) in the diabetic (247.0 +/- 22.8 mumol/mmol infused glucose) than in normal (315 +/- 16.3 mumol/mmol infused glucose rats) rats. The lactate produced was significantly higher in diabetic than in normal rats whether the preparations were perfused under isoglycemic (P < 0.01; 1916.4 +/- 124.0 vs vs 1284 +/- 67.7 mumol/mmol consumed glucose) or hyperglycemic (P < 0.05; 1356.4 +/- 199.7 vs 898.0 +/- 87.3 mumol/mmol consumed glucose) conditi...Continue Reading

References

Sep 8, 1975·Biochimica Et Biophysica Acta·H J Leese, J R Bronk
Apr 1, 1986·Diabetologia·A D MooradianR L Gebhard
Dec 1, 1971·The Journal of Clinical Investigation·J WahrenL Jorfeldt
Apr 1, 1968·The American Journal of Physiology·P Flores, H P Schedl
Apr 15, 1983·The Biochemical Journal·T J NichollsJ R Bronk
May 1, 1982·The American Journal of Physiology·G Suarez-Kurtz

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Citations

May 6, 2015·Canadian Journal of Physiology and Pharmacology·Emil FischerPál Perjési

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