Abstract
Rapid ventricular pacing (RVP) is a well-established animal model of atrial fibrillation (AF). However, this model is limited by a high mortality rate and severe heart failure. The purpose of our study was to assess a new canine model of inducible AF. We performed acute, short-term, simultaneous atrioventricular pacing (SAVP) and RVP (in random order) in 14 dogs for 30 s. SAVP produced more echocardiographic pulmonary venous flow reversal, a greater increase in mean pulmonary capillary wedge pressure, and a significantly greater decrease in left atrial emptying function (-84.4 +/- 38.6% vs. -23.7 +/- 27.1%, P < 0.05) than RVP. Thirty dogs were randomized to three, longer-term, study groups: eight dogs in the control group (no pacing), eight dogs in the RVP group (2 wk at 240 beats/min followed by 3 wk at 220 beats/min), and fourteen dogs in the SAVP group (2 wk at 220 beats/min). SAVP induced less left ventricular dysfunction but more left atrial dysfunction than RVP. SAVP dogs had similar atrial effective refractory periods as RVP dogs but more heterogeneity in conduction and more AF inducibility (83% vs. 40%, P < 0.05) and maintenance (median 1,660 vs. 710 s, P < 0.05) than RVP dogs. SAVP induced more collagen turnover and wa...Continue Reading
References
Jan 1, 1990·Canadian Journal of Physiology and Pharmacology·P J O'BrienP W Armstrong
Jul 1, 1990·Circulation·L S KleinD P Zipes
Sep 1, 1984·Journal of the American College of Cardiology·J A ErlebacherP E Stelzer
Mar 1, 1995·Circulation·C A MorilloC M Guiraudon
Apr 1, 1995·Journal of the American College of Cardiology·K OhtaniT Kamada
Jul 1, 1996·The American Journal of Physiology·J WangS Nattel
Aug 1, 1997·Journal of the American College of Cardiology·P H PakD A Kass
May 18, 1999·European Heart Journal·K KamalvandN Sulke
Jul 7, 1999·Circulation·D LiS Nattel
Oct 26, 1999·Cardiovascular Research·G W Moe, P Armstrong
Jun 7, 2000·Circulation·D LiS Nattel
Feb 7, 2001·Circulation·M A AllessieA L Waldo
Oct 31, 2001·Cardiovascular Research·Y ShiJ C Tardif
May 1, 2002·Circulation·Takahiro KouraSatoshi Ogawa
Jan 30, 2003·Journal of Cardiac Failure·Thomas ForceSyed Haq
Jan 13, 2004·Journal of the American College of Cardiology·Anjum KhanBradley H Strauss
Jan 14, 2004·Circulation·Tae-Joon ChaStanley Nattel
Jan 21, 2004·Circulation·Jun XuLuyi Sen
Mar 9, 2004·Journal of Vascular Research·David W CourtmanMichelle P Bendeck
Mar 17, 2004·Heart·A BoldtS Dhein
May 1, 2004·Circulation Research·Sander VerheuleJeffrey E Olgin
Jul 14, 2004·Cardiovascular Research·Nessrine HannaStanley Nattel
Dec 25, 2004·European Heart Journal·Cristina BanfiPiergiuseppe Agostoni
Jun 3, 2005·American Journal of Physiology. Cell Physiology·Fabio CarrozzinoRoberto Montesano
Jul 9, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tomotsugu TabataJames D Thomas
Sep 13, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Zoran B PopovićJames D Thomas
Oct 1, 2005·Progress in Cardiovascular Diseases·Stanley NattelLéna Rivard
Jan 24, 2006·Cardiovascular Research·Anne M Deschamps, Francis G Spinale
Apr 25, 2006·Immunology·Razi Khan, Richard Sheppard
Jul 5, 2006·Circulation·Jose M GuerraJeffrey E Olgin
Aug 7, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel ScherrJun Dong
Citations
Dec 19, 2013·The Journal of International Medical Research·Mingjiang LiCongxin Huang
Aug 10, 2010·Clinical Pediatrics·Raul R SilvaRafael Muniz
Sep 10, 2017·Circulation. Arrhythmia and Electrophysiology·Shouvik K HaldarKumaraswamy Nanthakumar
Jan 5, 2014·Journal of Cardiovascular Electrophysiology·Joanna Monigatti-TenkorangEtienne Pruvot
Nov 20, 2015·BioMed Research International·Bruno Gouvêa de BarrosSergio Alonso