PMID: 6166613Jan 1, 1981Paper

Experimental studies on insecticides commonly used in India

Journal of Cancer Research and Clinical Oncology
S K NigamS K Chatterjee

Abstract

Using hexachlorocyclohexane (BHC) as a model histopathological, histoenzymological, biochemical, and electrophoretic studies were undertaken to find out certain parameters for early diagnosis of liver cancer. In addition, cytogenetic studies were carried out to evaluate the effect of BHC feeding on mitotic and meiotic divisions. The results of these investigations suggest that there is a significant change in liver weight in experimental group. Histologically, liver cells follow a definite sequential cellular alteration ultimately leading to liver tumor. Histochemically, well defined pattern of glycogen accumulation and iron distribution in hepatocytes was observed. The electron-microscopic observation demonstrated prominently the proliferation of agranular endoplasmic reticulum in early stages. The distribution of certain enzymes linked with plasma membrane, lysosomes, and mitochondria showed the functional alteration of these organelles both in neoplastic nodules and tumours induced by BHC. The biochemical changes observed in gluconeogenic enzymes (G6Pase and F1,6dipase) and dehydrogenases (LDH, ICDH, and MDH) at different duration of exposure to BHC indicated decrease in enzyme activity of both gluconeogenic pathway and tric...Continue Reading

References

Jan 1, 1979·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·S K KashyapS K Chatterjee
May 15, 1977·International Journal of Cancer. Journal International Du Cancer·S K KashyapS K Chatterjee
Aug 1, 1967·Analytical Biochemistry·A A Dietz, T Lubrano
Feb 1, 1969·Archives of Environmental Health·A Curley, R Kimbrough
Dec 28, 1964·Annals of the New York Academy of Sciences·L ORNSTEIN
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

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Citations

Jan 1, 1986·International Archives of Occupational and Environmental Health·S K NigamB B Chatterjee
Mar 1, 1993·Mutation Research·M A JacksonM D Waters
Oct 28, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Devendra Kumar Bhatt, Mehajbeen Bano
Nov 8, 2012·Journal of Biochemical and Molecular Toxicology·Devendra Kumar Bhatt, Girima Nagda
Jan 1, 1988·Annals of the New York Academy of Sciences·S K NigamB H Joshi
Sep 1, 2007·Integrative Cancer Therapies·Neha P TrivediBeena P Patel
Aug 15, 2009·Integrative Cancer Therapies·Neha P TrivediBeena P Patel
Mar 9, 2019·Acta Anaesthesiologica Scandinavica·Sophie LindgrenOla Stenqvist
Mar 21, 2018·Psychonomic Bulletin & Review·Philip L Smith, Daniel R Little
Jan 1, 1989·Annals of the New York Academy of Sciences·E Kinne-Saffran

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